Recombinant Mouse M-phase inducer phosphatase 1 (Cdc25a)

1. Our results identify Cdc25A as a potential target for neuroprotectant strategy for the treatment of delayed ischemic neuronal death. PMID:28607169
2. CDC25A-deficient embryonic stem cells resist high doses of ATR inhibitors, which we show is due to their failure to prematurely enter mitosis in response to the drugs. PMID:27067599
3. These results showed that IGF1 regulated the expression of BOULE and CDC25A mRNAs via ERK1/2 signaling and in T-independent pathway during spermatogenesis in the adult mouse testes. PMID:25726377
4. accelerated cholangiocyte cystogenesis is likely due to overexpression of Cdc25A PMID:24211536
5. Cdc25A activity is required for the metaphase II arrest in mouse oocytes. PMID:23345398
6. deletion of Cdc25a increased apoptosis and accelerated the elimination of DNA damage following UV PMID:22764135
7. In the DNA damage response, instead of inhibiting cyclin B-CDK1 through destruction of Cdc25A phosphatase, oocytes utilize an inhibitory phosphorylation of Cdc25B. PMID:22578416
8. Cdc25A inhibitors block cell-cycle progression and proliferation, reduce liver and kidney weights and cyst growth in animal models of polycystic kidney/liver disease. PMID:22155366
9. CDC25A and CDC25B but not CDC25C compensate for each other to maintain the proliferative capacity of intestinal epithelial stem and progenitor cells PMID:21283624
10. IL-7 drives Cdc25A-mediated T-cell proliferation, which prevents the nuclear translocation of Foxo1, leading to reduced expression of CD62L and the migration of T cells into circulation. PMID:20831893
11. Results reveal an unexpected role of Cdc25A down-regulation and the inhibitory phosphorylation of cdk2 T14 and Y15 in cell cycle quiescence during muscle differentiation and implicate miRNAs-322 and -503 in the process. PMID:20462953
12. Cdc25A degradation does not inhibit Cdk2 activity because a considerable proportion of Cdk2 molecules localize to the cytoplasm and centrosomes in mESCs, where they may be sheltered from regulation by nuclear Cdc25A. PMID:20104581
13. human papillomavirus type 16 E7 maintains elevated levels of the cdc25A tyrosine phosphatase during deregulation of cell cycle arrest PMID:11752153
14. Identification of epidermal growth factor receptor as a target of Cdc25A protein phosphatase PMID:11912208
15. Studies of a transgenic mouse mammary tumor model identify Cdc25A as a candidate for human tumor latency modifier Apmt2. PMID:12045150
16. A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. PMID:12411323
17. TGF-beta stimulates p160ROCK translocation to the nucleus and inhibitory phosphorylation of the cyclin-dependent kinase-activating phosphatase, Cdc25A. PMID:14657354
18. In lymphocyte cell lines dependent on interleukin-3 or interleukin-7, or primary lymphocytes dependent on interleukin 7, the phosphatase Cdc25A is the critical mediator of proliferation. PMID:15928203
19. Chk1/Cdc25A activity participates in activation of a cell cycle pathway-mediated death signal in neurons. PMID:16928871
20. Cdc25A plays a rate-limiting role in transformation and tumor initiation mediated by ras activation PMID:17638870
21. CDC25A is not only a major regulator of both G(1)/S and G(2)/M transition during unperturbed cell cycle progression, but also a critical checkpoint mediator.[review] PMID:18073536
22. restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability [review] PMID:18316586
23. These data demonstrate that CDC25A behaves differently during female meiosis than during mitosis, and moreover, that CDC25A has a function in resumption of meiosis, spindle formation and the Meiosis I-Meiosis II transition. PMID:18367163
24. Cdc25A promotes G2/M transition in mouse oocytes. PMID:18418039
25. Results indicate that Cdc25A S123 phosphorylation is crucial for coupling centrosome duplication to DNA replication cycles after DNA damage and therefore is likely to play a role in the regulation of tumorigenesis. PMID:18936171
26. CDC25A is the only family member to provide an essential function during early embryonic development, and other family members compensate for its loss in adult mice. PMID:19273838
27. The expression of the dual specificity phosphatase CDC25A, is deregulated in Ba/F3 cells expressing the oncogenic protein NPM/ALK and in human cell lines derived from NPM/ALK-positive anaplastic large cell lymphomas. PMID:19305144

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UNIGENE: Mm.307103

KEGG: mmu:12530

STRING: 10090.ENSMUSP00000091882