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Recombinant Mouse Long-chain fatty acid transport protein 4 (Slc27a4), partial

Recombinant Mouse Long-chain fatty acid transport protein 4 (Slc27a4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Slc27a4

Purity

>85% (SDS-PAGE)

Target Names

Slc27a4

Uniprot NO.

Q91VE0

Alternative Names

Slc27a4; Acsvl4; Fatp4; Long-chain fatty acid transport protein 4; FATP-4; Fatty acid transport protein 4; Arachidonate--CoA ligase; Long-chain-fatty-acid--CoA ligase; Solute carrier family 27 member 4; Very long-chain acyl-CoA synthetase 4; ACSVL4

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (VLCFAs). Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Probably involved in fatty acid transport across the blood barrier. Indirectly inhibits RPE65 via substrate competition and via production of VLCFA derivatives like lignoceroyl-CoA. Prevents light-induced degeneration of rods and cones.

Gene References into Functions

a spontaneous Fatp4/Scl27a4 splice site mutation in congenital ichthyosis PMID:23226340
FATP4 plays crucial roles in the development and maturation of both sebaceous and meibomian glands, as well as in the formation and composition of sebum PMID:23271751
A key role was demonstrated for FATP4 in oleic acide-induced GLP-1 secretion from the murine intestinal L cell in vitro and in vivo. PMID:22871340
even though hypoxia regulates the expression of FATP2 and FATP4 in human trophoblasts, mouse Fatp2 and Fatp4 are not essential for intrauterine fetal growth. PMID:22028793
FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of CC muscle cells. PMID:21750264
adipocyte-specific Fatp4 deficiency results in adipose hypertrophy and profound alterations in the metabolism of complex lipids. PMID:21808061
identification of critical role in skin and hair development PMID:12697906
Fatp4-null mice displayed features of a neonatally lethal restrictive dermopathy. Lipid analysis demonstrated a disturbed fatty acid composition of epidermal ceramides. PMID:12821645
role in fat absorption in early embryogenesis and suggests a novel requirement for function during development PMID:14512415
FATP4 exhibits intrinsic acyl-coa synthetase activity and is a high velocity enzyme relative to FATP1. PMID:15653672
Fatp4 in epidermal keratinocytes is essential for the maintenance of a normal epidermal structure. PMID:16354193
FATP4 drives fatty acid uptake indirectly by esterification. It is not a transporter protein involved in fatty acid translocation at the plasma membrane. PMID:17062637
in murine skin fibroblasts, FATP4 is the major enzyme producing very long chain fatty acid-CoA for lipid metabolic pathways PMID:17522045
Fatp4(-/-);Ivl-Fatp4(tg/+) mice and wild-type littermates displayed indistinguishable food consumption, growth, and weight gain on either low or high fat (Western) diets, with no differences in intestinal triglyceride (TG) absorption or fecal fat losses. PMID:18843142

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Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Protein Families

ATP-dependent AMP-binding enzyme family

Tissue Specificity

Most abundantly expressed in small intestine, brain, kidney, liver, skin and heart. In small intestine, expressed at high levels on the apical side of mature enterocytes. Highly expressed by the epithelial cells of the visceral endoderm and localized to t

Database Links

UNIGENE: Mm.330113

KEGG: mmu:26569

STRING: 10090.ENSMUSP00000078971

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