Recombinant Mouse Leukocyte immunoglobulin-like receptor subfamily B member 4 (Lilrb4), partial

1. Targeting hepatic LILRB4 to improve its expression or activation represents a promising strategy for the treatment of non alcoholic fatty liver diseases as well as related liver and metabolic diseases PMID:29091299
2. Results suggest that plasma cell development from memory and marginal zone B cells, as well as subsequent antibody production, are suppressed via glycoprotein 49B (gp49B). PMID:24935931
3. LILRB4 can downregulate the development of pathologic allergic inflammation. PMID:23431396
4. receptor attenuates the number of these mature DCs and attendant IL-4-producing lymphocytes in the lymph nodes, and accordingly, the ability of DCs to elicit pathologic Th2 pulmonary inflammation PMID:19966208
5. Inhibition of anaphylactic inflammation by the gp49B1 receptor on mast cells. PMID:12217399
6. Gp49B1 is a unique inhibitory receptor that is induced in multiple lineages of innate and adaptive immune cells during an infection and controls their IFN-gamma, but not cytotoxic responses. PMID:12682239
7. Expression of gp49B was detected on peripheral eosinophils of control mice and on eosinophils from lungs of mice treated with RW, suggesting a role for gp49B on eosinophils in dampening allergic inflammatory responses. PMID:17761953
8. study reports that gp49B, is expressed on dendritic cells and downregulates cellular activity to prevent the excessive activation of T cells in vitro and in vivo PMID:18792399

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UNIGENE: Mm.34408

KEGG: mmu:14728

STRING: 10090.ENSMUSP00000077833