Recombinant Mouse Leukemia inhibitory factor receptor (Lifr), partial

1. Authors demonstrate heterozygous novel or rare LIFR mutations in 3.3% of CAKUT patients, and provide evidence that Lifr deficiency and deactivating LIFR mutations cause highly similar anomalies of the urogenital tract in mice and humans. PMID:28334964
2. uterine expression of the LIFR is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation. PMID:28368537
3. OSM (mOSM) signals mainly via an OSM receptor (OSMR)-gp130 heterodimer and binds with only very low affinity to mLIFR. PMID:27539849
4. The predominant role of leukemia inhibitory factor receptor in skeletal muscle regeneration appears to be in regulating the inflammatory response rather than directly effecting myogenic cells. PMID:22926285
5. Data confirmed that LIF and the LIFR were up-regulated in intra-implantation sites compared to inter-implantation sites on Day 5 of gestation. PMID:21966484
6. Neuropoietin induced activation of STAT3 tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation. PMID:20353755
7. Review. The structure and function of the LIF-R gene and protein and the role of its cytoplasmic domain in myeloid leukemia cells are reviewed. PMID:11042511
8. directly prevents oligodendrocyte death in animal models of multiple sclerosis PMID:12042813
9. LIFR plays a role in modulating fetal response to high maternal glucocorticoids in late gestation, likely mediated through the glucocorticoid receptor, with implications for adult homeostasis as a direct tie between immune, neural & hormone function. PMID:12823859
10. LIFR signaling can exert negative regulatory effects on neurite extension and branching of sympathetic neurons PMID:12871977
11. Although not necessary for neural stem cell self-renewal, LIFR activation enhances both the clonogenicity and expression of glial fibrillary acid protein (GFAP) by these multipotential cells. PMID:15519241
12. Lifr -/- mice demonstrate elevated pituitary glucocorticoid (GR) and mineralocorticoid (MR) receptor mRNA and protein levels, indicating the importance of LIF signaling for hypothalamic-pituitary adrenal axis development. PMID:16081071
13. Data show that demyelination induces oligodendrocyte expression of SOCS3, that this induction depends on leukemia inhibitory factor (LIF) and LIF receptors, and that endogenous LIF may be a key determinant of the CNS response to oligodendrocyte loss. PMID:16682639
14. provides a structural template to understand the formation and orientation of the high-affinity signaling complex between LIF, LIF receptor, and gp130 PMID:17652170
15. From the analysis of lifr beta mutant embryos, it was established that LIFR beta is necessary for fbm neurons' identity determination and is implicated in astrocyte and oligodendrocyte differentiation, specifically within the facial nucleus. PMID:18031722
16. Endogenous LIF is an immunologically active molecule in neuroinflammation. PMID:18250427
17. These data demonstrate that LIFR and its ligands play an essential role in endogenous neuroprotective mechanisms triggered by preconditioning-induced stress. PMID:19344761

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UNIGENE: Mm.149720

KEGG: mmu:16880

STRING: 10090.ENSMUSP00000064551