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Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6), partial

Recombinant Mouse Leucine-rich repeat-containing G-protein coupled receptor 6 (Lgr6), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Lgr6

Purity

>85% (SDS-PAGE)

Target Names

Lgr6

Uniprot NO.

Q3UVD5

Alternative Names

Lgr6Leucine-rich repeat-containing G-protein coupled receptor 6

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal.

Gene References into Functions

Leucine rich repeat containing G protein coupled receptor 6 (Lgr6) mRNA was found to be diminished in skin tumors. PMID:27880932
Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma whose expression is proportional with the disease progression. PMID:28945253
Lgr6 marks mammary gland progenitor cells that can initiate tumours, and cells of luminal breast tumours required for efficient tumour maintenance. PMID:27798604
Lgr6 marks nail stem cells and is required for digit tip regeneration. PMID:26460010
Lgr6 and Bmi1 have roles in stem cells in the acral epithelium that participate in the long-term maintenance of sweat glands, ducts, and interadnexal epidermis, while Lgr5 has a role in rapid cycling and maintance of sweat glands only PMID:26362184
Lgr6 is expressed in cells at the basal area of taste buds in fungiform and circumvallate papillae. Lgr6+ cells give rise to taste bud cells in taste papillae in both anterior and posterior tongue. PMID:25368147
Lgr5 has been identified as a marker of Wnt-regulated adult stem cell populations in the hair-follicle, intestine and stomach. A closely-related protein, Lgr6 marks adult stem cells responsible for fueling the renewal of the sebaceous gland and skin.[Review] PMID:22002312
study concludes that Lgr6 marks the most primitive epidermal stem cell PMID:20223988