Home
Product
Protein
Recombinant Proteins
Recombinant Mouse Laminin subunit alpha-5 (Lama5), partial

Recombinant Mouse Laminin subunit alpha-5 (Lama5), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Lama5

Purity

>85% (SDS-PAGE)

Target Names

Lama5

Uniprot NO.

Q61001

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

41-3718

Target Protein Sequence

RTPGGDGFSL HPPYFNLAEG ARITASATCG EEAPTRSVSR PTEDLYCKLV GGPVAGGDPN QTIQGQYCDI CTAANSNKAH PVSNAIDGTE RWWQSPPLSR GLEYNEVNVT LDLGQVFHVA YVLIKFANSP RPDLWVLERS TDFGHTYQPW QFFASSKRDC LERFGPRTLE RITQDDDVIC TTEYSRIVPL ENGEIVVSLV NGRPGALNFS YSPLLRDFTK ATNIRLRFLR TNTLLGHLMG KALRDPTVTR RYYYSIKDIS IGGRCVCHGH ADVCDAKDPL DPFRLQCACQ HNTCGGSCDR CCPGFNQQPW KPATTDSANE CQSCNCHGHA YDCYYDPEVD RRNASQNQDN VYQGGGVCLD CQHHTTGINC ERCLPGFFRA PDQPLDSPHV CRPCDCESDF TDGTCEDLTG RCYCRPNFTG ELCAACAEGY TDFPHCYPLP SFPHNDTREQ VLPAGQIVNC DCNAAGTQGN ACRKDPRLGR CVCKPNFRGA HCELCAPGFH GPSCHPCQCS SPGVANSLCD PESGQCMCRT GFEGDRCDHC ALGYFHFPLC QLCGCSPAGT LPEGCDEAGR CQCRPGFDGP HCDRCLPGYH GYPDCHACAC DPRGALDQQC GVGGLCHCRP GYTGATCQEC SPGFYGFPSC IPCHCSADGS LHTTCDPTTG QCRCRPRVTG LHCDMCVPGA YNFPYCEAGS CHPAGLAPAN PALPETQAPC MCRAHVEGPS CDRCKPGYWG LSASNPEGCT RCSCDPRGTL GGVTECQGNG QCFCKAHVCG KTCAACKDGF FGLDYADYFG CRSCRCDVGG ALGQGCEPKT GACRCRPNTQ GPTCSEPAKD HYLPDLHHMR LELEEAATPE GHAVRFGFNP LEFENFSWRG YAHMMAIQPR IVARLNVTSP DLFRLVFRYV NRGSTSVNGQ ISVREEGKLS SCTNCTEQSQ PVAFPPSTEP AFVTVPQRGF GEPFVLNPGI WALLVEAEGV LLDYVVLLPS TYYEAALLQH RVTEACTYRP SALHSTENCL VYAHLPLDGF PSAAGTEALC RHDNSLPRPC PTEQLSPSHP PLATCFGSDV DIQLEMAVPQ PGQYVLVVEY VGEDSHQEMG VAVHTPQRAP QQGVLNLHPC PYSSLCRSPA RDTQHHLAIF YLDSEASIRL TAEQAHFFLH SVTLVPVEEF STEFVEPRVF CVSSHGTFNP SSAACLASRF PKPPQPIILK DCQVLPLPPD LPLTQSQELS PGAPPEGPQP RPPTAVDPNA EPTLLRHPQG TVVFTTQVPT LGRYAFLLHG YQPVHPSFPV EVLINGGRIW QGHANASFCP HGYGCRTLVL CEGQTMLDVT DNELTVTVRV PEGRWLWLDY VLIVPEDAYS SSYLQEEPLD KSYDFISHCA TQGYHISPSS SSPFCRNAAT SLSLFYNNGA LPCGCHEVGA VSPTCEPFGG QCPCRGHVIG RDCSRCATGY WGFPNCRPCD CGARLCDELT GQCICPPRTV PPDCLVCQPQ SFGCHPLVGC EECNCSGPGV QELTDPTCDM DSGQCRCRPN VAGRRCDTCA PGFYGYPSCR PCDCHEAGTM ASVCDPLTGQ CHCKENVQGS RCDQCRVGTF SLDAANPKGC TRCFCFGATE RCGNSNLARH EFVDMEGWVL LSSDRQVVPH EHRPEIELLH ADLRSVADTF SELYWQAPPS YLGDRVSSYG GTLHYELHSE TQRGDIFIPY ESRPDVVLQG NQMSIAFLEL AYPPPGQVHR GQLQLVEGNF RHLETHNPVS REELMMVLAG LEQLQIRALF SQTSSSVSLR RVVLEVASEA GRGPPASNVE LCMCPANYRG DSCQECAPGY YRDTKGLFLG RCVPCQCHGH SDRCLPGSGI CVGCQHNTEG DQCERCRPGF VSSDPSNPAS PCVSCPCPLA VPSNNFADGC VLRNGRTQCL CRPGYAGASC ERCAPGFFGN PLVLGSSCQP CDCSGNGDPN MIFSDCDPLT GACRGCLRHT TGPHCERCAP GFYGNALLPG NCTRCDCSPC GTETCDPQSG RCLCKAGVTG QRCDRCLEGY FGFEQCQGCR PCACGPAAKG SECHPQSGQC HCQPGTTGPQ CLECAPGYWG LPEKGCRRCQ CPRGHCDPHT GHCTCPPGLS GERCDTCSQQ HQVPVPGKPG GHGIHCEVCD HCVVLLLDDL ERAGALLPAI REQLQGINAS SAAWARLHRL NASIADLQSK LRSPPGPRYQ AAQQLQTLEQ QSISLQQDTE RLGSQATGVQ GQAGQLLDTT ESTLGRAQKL LESVRAVGRA LNELASRMGQ GSPGDALVPS GEQLRWALAE VERLLWDMRT RDLGAQGAVA EAELAEAQRL MARVQEQLTS FWEENQSLAT HIRDQLAQYE SGLMDLREAL NQAVNTTREA EELNSRNQER LKEALQWKQE LSQDNATLKA TLQAASLILG HVSELLQGID QAKEDLEHLA ASLDGAWTPL LKRMQAFSPA SSKVDLVEAA EAHAQKLNQL AINLSGIILG INQDRFIQRA VEASNAYSSI LQAVQAAEDA AGQALRQASR TWEMVVQRGL AAGARQLLAN SSALEETILG HQGRLGLAQG RLQAAGIQLH NVWARKNQLA AQIQEAQAML AMDTSETSEK IAHAKAVAAE ALSTATHVQS QLQGMQKNVE RWQSQLGGLQ GQDLSQVERD ASSSVSTLEK TLPQLLAKLS RLENRGVHNA SLALSANIGR VRKLIAQARS AASKVKVSMK FNGRSGVRLR TPRDLADLAA YTALKFHIQS PVPAPEPGKN TGDHFVLYMG SRQATGDYMG VSLRNQKVHW VYRLGKAGPT TLSIDENIGE QFAAVSIDRT LQFGHMSVTV EKQMVHEIKG DTVAPGSEGL LNLHPDDFVF YVGGYPSNFT PPEPLRFPGY LGCIEMETLN EEVVSLYNFE QTFMLDTAVD KPCARSKATG DPWLTDGSYL DGSGFARISF EKQFSNTKRF DQELRLVSYN GIIFFLKQES QFLCLAVQEG TLVLFYDFGS GLKKADPLQP PQALTAASKA IQVFLLAGNR KRVLVRVERA TVFSVDQDNM LEMADAYYLG GVPPEQLPLS LRQLFPSGGS VRGCIKGIKA LGKYVDLKRL NTTGISFGCT ADLLVGRTMT FHGHGFLPLA LPDVAPITEV VYSGFGFRGT QDNNLLYYRT SPDGPYQVSL REGHVTLRFM NQEVETQRVF ADGAPHYVAF YSNVTGVWLY VDDQLQLVKS HERTTPMLQL QPEEPSRLLL GGLPVSGTFH NFSGCISNVF VQRLRGPQRV FDLHQNMGSV NVSVGCTPAQ LIETSRATAQ KVSRRSRQPS QDLACTTPWL PGTIQDAYQF GGPLPSYLQF VGISPSHRNR LHLSMLVRPH AASQGLLLST APMSGRSPSL VLFLNHGHFV AQTEGPGPRL QVQSRQHSRA GQWHRVSVRW GMQQIQLVVD GSQTWSQKAL HHRVPRAERP QPYTLSVGGL PASSYSSKLP VSVGFSGCLK KLQLDKRPLR TPTQMVGVTP CVSGPLEDGL FFPGSEGVVT LELPKAKMPY VSLELEMRPL AAAGLIFHLG QALATPYMQL KVLTEQVLLQ ANDGAGEFST WVTYPKLCDG RWHRVAVIMG RDTLRLEVDT QSNHTTGRLP ESLAGSPALL HLGSLPKSST ARPELPAYRG CLRKLLINGA PVNVTASVQI QGAVGMRGCP SGTLALSKQG KALTQRQAKP SVSPLLWH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Alpha-5 may be the major laminin alpha chain of adult epithelial and/or endothelial basal laminae.

Gene References into Functions

the overriding effect of laminin 511 in the skin is inhibition of basal keratinocyte proliferation and migration. PMID:27234307
Study found that the extracellular matrix protein laminin-511 (LM511) promoted the survival and differentiation of dopaminergic neurons in the midbrain neurons. LM511 bound to integrin alpha3beta1 and activated the transcriptional cofactor YAP. PMID:28831020
Using standard histological analyses and electron microscopy, we characterized the morphology of the external genitalia in Lama5 knockout (LAMA5-KO) mouse embryos during both androgen-independent genital tubercle development and androgen-mediated sexual differentiation PMID:27208857
The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress. PMID:27940654
According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time. PMID:27064881
Data suggest that the proper expression of laminin-332 (Lamb3) and laminin-511 (lama5) may regulate appropriate hair morphogenesis. PMID:23529140
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes. PMID:24036115
Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold. PMID:23755407
These results suggest that laminin trimers containing alpha5 that are synthesized and secreted by endothelium or by trophoblasts are capable of integrating into the basement membrane and promoting normal vascularization of the placenta. PMID:22911783
mechanistic role of laminin-511 in tissue homeostasis PMID:22666383
amino acid residues within the short arm region of alpha5 that were critical for neurite outgrowth activity PMID:22621685
crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network PMID:21311558
Downregulation of laminin-511 is important for hair regression. PMID:20226633
role in lobar septation and visceral pleural basement membrane formation in developing mouse lung PMID:12051813
several peptides of Laminin alpha 5 had cell attachment activity and the ability to promote neurite outgrowth. PMID:12061820
Results demonstrate that the alpha5 LG3 module is essential for the Lutheran blood group glycoprotein (Lu) binding to laminin alpha5. PMID:12244066
Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the G domain of this protein. PMID:12519075
Data suggest that laminin-10 (alpha5beta1gamma1) is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect. PMID:12743034
the laminin alpha5 chain is essential for normal development of the intestinal smooth muscle and point to possible mesenchyme-derived compensation to promote normal intestinal morphogenesis when laminin alpha5 is absent. PMID:12921739
crucial role for the LG4 module of laminin-alpha5 in epithelial morphogenesis that is distinct from that of the laminin-alpha1 LG4. PMID:14568553
Cryptic matrix epitope AQARSAASKVKVSMKF of laminin alpha 5 induces diverse inflammatory cell activities, including chemotaxis and expression of proteinases, cytokines, and cytokine receptors. PMID:15661925
Epithelial laminin alpha5 is necessary for murine lung development through signaling pathways that promote alveolar epithelial cell differentiation and VEGF expression. PMID:15936333
Laminin alpha5, a gene up-regulated during neural crest induction, is localized in regions of newly formed cranial and trunk neural folds and adjacent neural crest migratory pathways in a manner largely conserved between chick and mouse. PMID:16316641
A new mouse PKD model has been produced through insertion of a PGKneo cassette in an intron of the gene that encodes laminin alpha5 (Lama5). Lama5neo/neo mice exhibit PKD, proteinuria, and death from renal failure by 4 wk of age. PMID:16790509
The major contributions of laminin-5 to the resistance of the epidermis against frictional stress but also for basement membrane regeneration and repair of damaged skin are reflected by the phenotype of Herlitz junctional epidermolysis bullosa. PMID:17000025
podocyte foot process differentiation may require direct exposure to laminin alpha5 PMID:17599968
Laminin alpha 5 has a crucial role in establishing and maintaining the specific mucosal pattern of the mouse small intestine PMID:18628307
Laminin alpha5 directly inhibits integrin alpha(6)beta(1)-mediated migration of T lymphocytes through laminin alpha4. PMID:19396173

Hide All

Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Tissue Specificity

In adult, high levels in heart, lung, and kidney; lower in brain, muscle and testis; very low in liver, gut and skin. Expressed in many tissues in embryonic day 11.

Database Links

UNIGENE: Mm.4339

KEGG: mmu:16776

STRING: 10090.ENSMUSP00000015791

Promotions