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Recombinant Mouse Laminin subunit alpha-4 (Lama4), partial

Recombinant Mouse Laminin subunit alpha-4 (Lama4), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Lama4

Uniprot NO.

P97927

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

25-1816

Target Protein Sequence

ASGDGN AFPFDIEGSA VVGRQDPSET SDSGVTLGRL PPAAERCDAG FFRTLSGECA PCDCNGNSHE CLDGSGFCLH CQRNTTGEHC EKCLDGYIGD SIRGTPRFCQ PCPCPLPHLA NFAESCYRKN GAVRCICKEN YVGPNCERCA PGYYGNPLLI GSTCKKCDCS GNSDPNLIFE DCDEITGQCR NCLRNTTGFK CERCAPGYYG DARTAKNCAV CNCGGGPCDS VTGECLEEGF EVPTGCDKCV WDLTDDLRLA ALSIEESKSG LLSVSSGAAA HRHVTDMNST IHLLRTRLSE RENQYTLRKI QINNSENTLR SLLPDVEGLH EKGSQASRKG MLVEKESMDT IDQATHLVEQ AHNMRDKIQE INSKMLYYGE NQELGPEEIA EKLVLAQKML EEIRSRQPFL THRELVDEEA DEAQELLSQA ENWQRLHNDT RSLFPVVLEQ LDDYNAKLSD LQESINQALD HVRDAEDMNR AITFKQRDHE KQHERVKEQM EVVGASLSMS ADSLTIPQLT LEELDEIIKN ASGIYAEIDG AKNELQGKLS NLSNLSHDLV QEATDHAYNL QQEADELSRN LHSSDMNGLV QKALDASNVY ENIANYVSEA NETAELALNI TDRIYDAVSG IDTQIIYHKD ESDNLLNQAR ELQAKADSSN DEAVADTSRR VGGALWRKGA LRDRLNDAVK QLQAAERGDA HQRLGQSKLF IEEANKTTAA VQQVTTPMAN NLSNWSQNLQ TFDSSAYNTA VDSARDAVRN LTEVVPQLLD QLRTVEQKRP ASNISASIQR IRELIAQTRS VASKIQVSMM FDGQSAVEVH PKVSVDDLKA FTSISLYMKP PPKPAEPTGA WVADQFVLYL GSKNAKKEYM GLAIKNDNLV YVYNLGMKDV EILLDSKPVS SWPAYFSIVK IERVGKHGKV FLTVPSLSST AEEKFIKKGE FAGDDSLLDL TPEDTVFYVG GVPANFKLPA SLNLPSYSGC LELATLNNDV ISLYNFKHIY NMDPSKSVPC ARDKLAFTQS RAASYFFDGS SYAVVRDITR RGKFGQVTRF DIEIRTPADN GLVLLMVNGS MFFSLEMRNG YLHVFYDFGF SNGPVHLEDT LKKAQINDAK YHEISIIYHN DKKMILVVDR RHVKSTDNEK KKIPFTDIYI GGAPQEVLQS RTLRAHLPLD INFRGCMKGF QFQKKDFNLL EQTETLGVGY GCPEDSLISR RAYFNGQSFI ASIQKISFFD GFEGGFNFRT LQPNGLLFYY TSGSDVFSIS LDNGTVVMDV KGIKVMSTDK QYHDGLPHFV VTSISDTRYE LVVDKSRLRG KNPTKGKAEQ TQTTEKKFYF GGSPISPQYA NFTGCISNAY FTRLDRDVEV EDFQRYSEKV HTSLYECPIE SSPLFLLHKK GKNSSKPKTN KQGEKSKDAP SWDPIGLKFL EQKAPRDSHC HLSSSPRAIE HAYQYGGTAN SRQEFEHEQG DFGEKSQFAI RLKTRSSHGM IFYVSDQEEN DFMTLFLAHG RLVFMFNVGH KKLKIRSQEK YNDGLWHDVI FIREKSSGRL VIDGLRVLEE RLPPSGAAWK IKGPIYLGGV APGRAVKNVQ ITSVYSFSGC LGNLQLNGAS ITSASQTFSV TPCFEGPMET GTYFSTEGGY VVLDESFNIG LKFEIAFEVR PRSSSGTLVH GHSVNGEYLN VHMRNGQVIV KVNNGVRDFS TSVTPKQNLC DGRWHRITVI RDSNVVQLDV DSEVNHVVGP LNPKPVDHRE PVFVGGVPES LLTPRLAPSK PFTGCIRHFV IDSRPVSFSK AALVSGAVSI NSCPTA
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene References into Functions

Data (including data from studies in knockout mice) suggest that Lama4 is involved in regulation of energy metabolism, regulation of adiposity, and development of beige adipose tissue; here, Lama4 knockout mice exhibit significantly improved insulin sensitivity compared with wild-type mice, suggesting improved metabolic function. PMID:28973559
Results showed maintained perturbed transmission properties at lama4(-/-) NMJs from adult (3 months) through to aged (18-22 months). Hind-limb grip force demonstrated similar trends as transmission properties, with maintained weaker grip force across age groups in lama4(-/-). Interestingly, both transmission properties and hind-limb grip force in aged wild-types resembled those observed in adult lama4(-/-). PMID:28301326
Lama4-/- NMJs demonstrated a decrease in miniature end-plate potential (EPP) frequency and increased amplitude of miniature EPPs and evoked EPPs. PMID:27998908
laminin alpha4 influences adipose tissue structure and function in a depot-specific manner. PMID:25310607
Laminins affect T cell trafficking and allograft fate. PMID:24691446
synaptic laminin are required to maintain adult neuromuscular junctions. PMID:23056392
most of the integrin-mediated cell adhesive peptides are located in the loop regions in the G domains, suggesting that structure is important for the integrin specific recognition PMID:22391228
simultaneous deletion of collagen type XV from neural basement membrane zones with laminin alpha4 leads to a phenotype distinct from those of both single knock-outs PMID:20980607
The role of basement membrane laminin alpha4 in leukocyte recruitment to inflammatory loci, is addressed. PMID:20483922
Failure of laminin alpha4-mediated down-regulation of PDGF activity contributes to the progressive renal lesions in this animal model. PMID:20035058
biological functions of the laminin alpha 4 chain G domain and screening of active sites PMID:12130633
heparin-binding activity of laminin alpha4 laminin-G-like domain 4 PMID:15182231
The activity of a cyclic peptide from a region of laminin alpha 4 on the connecting loop between the E and F strands is highly conformation-dependent, suggesting that the E-F loop structure is crucial for its biological activity. PMID:15491165
peptides from the laminin alpha4 chain G domain promote neurite outgrowth activity via a specific conformation PMID:15823034
mutation in the laminin alpha4 chain leads to abnormal cardiovascular extracellular structure that cause insufficient oxygen supply to the heart in cardiomyopathy PMID:16204254
These results suggest that the cryptic alpha4 LG4-5 fragment derived from the laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of FGF-2 through syndecans. PMID:18067585
These results show that laminins alpha4, alpha5, and beta2 play an autocrine role in coordinating post- with presynaptic maturation. PMID:18794334
LM alpha4 and beta2 have roles in in vitro migration and in vivo tumorigenicity of prostate cancer cells PMID:19048114
Laminin alpha4 is needed for the stability of newly formed blood vessels and may play a role in angiogenesis. PMID:11809810

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Subcellular Location

Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.

Tissue Specificity

Strongly expressed in peripheral nerves, cardiac muscle, fat, dermis, lung stroma, aortic endothelium, endocardium and endothelium of blood vessels in skin and brain.

Database Links

UNIGENE: Mm.258065

KEGG: mmu:16775

STRING: 10090.ENSMUSP00000019992

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