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Recombinant Mouse Laminin subunit alpha-1 (Lama1), partial

Recombinant Mouse Laminin subunit alpha-1 (Lama1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Lama1

Uniprot NO.

P19137

Alternative Names

Lama1; Lama; Lama-1; Laminin subunit alpha-1; Laminin A chain; Laminin-1 subunit alpha; Laminin-3 subunit alpha; S-laminin subunit alpha; S-LAM alpha

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

25-3084

Target Protein Sequence

QQRGLF PAILNLATNA HISANATCGE KGPEMFCKLV EHVPGRPVRH AQCRVCDGNS TNPRERHPIS HAIDGTNNWW QSPSIQNGRE YHWVTVTLDL RQVFQVAYII IKAANAPRPG NWILERSVDG VKFKPWQYYA VSDTECLTRY KITPRRGPPT YRADNEVICT SYYSKLVPLE HGEIHTSLIN GRPSADDPSP QLLEFTSARY IRLRLQRIRT LNADLMTLSH RDLRDLDPIV TRRYYYSIKD ISVGGMCICY GHASSCPWDE EAKQLQCQCE HNTCGESCDR CCPGYHQQPW RPGTISSGNE CEECNCHNKA KDCYYDSSVA KERRSLNTAG QYSGGGVCVN CSQNTTGINC ETCIDQYYRP HKVSPYDDHP CRPCNCDPVG SLSSVCIKDD RHADLANGKW PGQCPCRKGY AGDKCDRCQF GYRGFPNCIP CDCRTVGSLN EDPCIEPCLC KKNVEGKNCD RCKPGFYNLK ERNPEGCSEC FCFGVSGVCD SLTWSISQVT NMSGWLVTDL MSTNKIRSQQ DVLGGHRQIS INNTAVMQRL TSTYYWAAPE AYLGNKLTAF GGFLKYTVSY DIPVETVDSD LMSHADIIIK GNGLTISTRA EGLSLQPYEE YFNVVRLVPE NFRDFNTRRE IDRDQLMTVL ANVTHLLIRA NYNSAKMALY RLDSVSLDIA SPNAIDLAVA ADVEHCECPQ GYTGTSCEAC LPGYYRVDGI LFGGICQPCE CHGHASECDI HGICSVCTHN TTGDHCEQCL PGFYGTPSRG TPGDCQPCAC PLSIDSNNFS PTCHLTDGEE VVCDQCAPGY SGSWCERCAD GYYGNPTVPG GTCVPCNCSG NVDPLEAGHC DSVTGECLKC LWNTDGAHCE RCADGFYGDA VTAKNCRACD CHENGSLSGV CHLETGLCDC KPHVTGQQCD QCLSGYYGLD TGLGCVPCNC SVEGSVSDNC TEEGQCHCGP GVSGKQCDRC SHGFYAFQDG GCTPCDCAHT QNNCDPASGE CLCPPHTQGL KCEECEEAYW GLDPEQGCQA CNCSAVGSTS AQCDVLSGHC PCKKGFGGQS CHQCSLGYRS FPDCVPCGCD LRGTLPDTCD LEQGLCSCSE DSGTCSCKEN VVGPQCSKCQ AGTFALRGDN PQGCSPCFCF GLSQLCSELE GYVRTLITLA SDQPLLHVVS QSNLKGTIEG VHFQPPDTLL DAEAVRQHIY AEPFYWRLPK QFQGDQLLAY GGKLQYSVAF YSTLGTGTSN YEPQVLIKGG RARKHVIYMD APAPENGVRQ DYEVQMKEEF WKYFNSVSEK HVTHSDFMSV LSNIDYILIK ASYGQGLQQS RIANISMEVG RKAVELPAEG EAALLLELCV CPPGTAGHSC QDCAPGYYRE KLPESGGRGP RPLLAPCVPC NCNNHSDVCD PETGKCLSCR DHTSGDHCEL CASGYYGKVT GLPGDCTPCT CPHHPPFSFS PTCVVEGDSD FRCNACLPGY EGQYCERCSA GYHGNPRAAG GSCQTCDCNP QGSVHSDCDR ASGQCVCKPG ATGLHCEKCL PRHILMESDC VSCDDDCVGP LLNDLDSVGD AVLSLNLTGV SPAPYGILEN LENTTKYFQR YLIKENAKKI RAEIQLEGIA EQTENLQKEL TRVLARHQKV NAEMERTSNG TQALATFIEQ LHANIKEITE KVATLNQTAR KDFQPPVSAL QSMHQNISSL LGLIKERNFT EMQQNATLEL KAAKDLLSRI QKRFQKPQEK LKALKEANSL LSNHSEKLQA AEELLKEAGS KTQESNLLLL LVKANLKEEF QEKKLRVQEE QNVTSELIAK GREWVDAAGT HTAAAQDTLT QLEHHRDELL LWARKIRSHV DDLVMQMSKR RARDLVHRAE QHASELQSRA GALDRDLENV RNVSLNATSA AHVHSNIQTL TEEAEMLAAD AHKTANKTDL ISESLASRGK AVLQRSSRFL KESVGTRRKQ QGITMKLDEL KNLTSQFQES VDNITKQAND SLAMLRESPG GMREKGRKAR ELAAAANESA VKTLEDVLAL SLRVFNTSED LSRVNATVQE TNDLLHNSTM TTLLAGRKMK DMEMQANLLL DRLKPLKTLE ENLSRNLSEI KLLISRARKQ AASIKVAVSA DRDCIRAYQP QTSSTNYNTL ILNVKTQEPD NLLFYLGSSS SSDFLAVEMR RGKVAFLWDL GSGSTRLEFP EVSINNNRWH SIYITRFGNM GSLSVKEASA AENPPVRTSK SPGPSKVLDI NNSTLMFVGG LGGQIKKSPA VKVTHFKGCM GEAFLNGKSI GLWNYIEREG KCNGCFGSSQ NEDSSFHFDG SGYAMVEKTL RPTVTQIVIL FSTFSPNGLL FYLASNGTKD FLSIELVRGR VKVMVDLGSG PLTLMTDRRY NNGTWYKIAF QRNRKQGLLA VFDAYDTSDK ETKQGETPGA ASDLNRLEKD LIYVGGLPHS KAVRKGVSSR SYVGCIKNLE ISRSTFDLLR NSYGVRKGCA LEPIQSVSFL RGGYVEMPPK SLSPESSLLA TFATKNSSGI LLVALGKDAE EAGGAQAHVP FFSIMLLEGR IEVHVNSGDG TSLRKALLHA PTGSYSDGQE HSISLVRNRR VITIQVDENS PVEMKLGPLT EGKTIDISNL YIGGLPEDKA TPMLKMRTSF HGCIKNVVLD AQLLDFTHAT GSEQVELDTC LLAEEPMQSL HREHGELPPE PPTLPQPELC AVDTAPGYVA GAHQFGLSQN SHLVLPLNQS DVRKRLQVQL SIRTFASSGL IYYVAHQNQM DYATLQLQEG RLHFMFDLGK GRTKVSHPAL LSDGKWHTVK TEYIKRKAFM TVDGQESPSV TVVGNATTLD VERKLYLGGL PSHYRARNIG TITHSIPACI GEIMVNGQQL DKDRPLSASA VDRCYVVAQE GTFFEGSGYA ALVKEGYKVR LDLNITLEFR TTSKNGVLLG ISSAKVDAIG LEIVDGKVLF HVNNGAGRIT ATYQPRAARA LCDGKWHTLQ AHKSKHRIVL TVDGNSVRAE SPHTHSTSAD TNDPIYVGGY PAHIKQNCLS SRASFRGCVR NLRLSRGSQV QSLDLSRAFD LQGVFPHSCP GPEP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

Gene References into Functions

laminin-1 does not have a positive effect on ENCC migration in HD mice on E12.5, in contrast to the phenomenon seen in normal mice gut specimens, where laminin-1 promotes ENCC migration during the same period. PMID:29018955
Altered LAMA1 expression in the aganglionic region may contribute to impaired ENCC migration, resulting in HD. These data could help in understanding the pathophysiologic interactions between LAMA1 and ENCC migration PMID:28983681
Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. PMID:27964993
Laminin differentially regulates the stemness of type I and type II pericytes. PMID:28173861
Laminin regulates PDGFRbeta cell differentiation, fate determination, cell stemness and muscle development via gpihbp1. PMID:27138650
while MMP-9 is not essential for hypoxic-induced cerebral angiogenesis, it plays an important role in post-hypoxic vascular pruning by degrading laminin and claudin-5 PMID:25812799
These findings suggest that LAMA1 plays a critical role in kidney function and kidney aging by regulating the mesangial cell population and mesangial matrix deposition through TGF-beta/Smad signaling. PMID:24720953
Mutations in Lama1 allow developing retinal vessels to enter the vitreous where they anastomose with vessels of the hyaloid system which persist and expand PMID:21999428
#NAME? PMID:22270369
Our data show that the absence of Lama1 has an impact on the Bergmann glia scaffold that aberrantly develops. PMID:22274713
Laminin alpha1 is essential for mouse cerebellar development. PMID:21983115
Laminin promotes epithelial formation of XEN cells, and up-regulation of visceral endoderm markers. PMID:22027433
Laminin alpha1 chain is not responsible for muscle disease in the mdx mouse model for Duchenne muscular dystrophy PMID:21435454
The results show that laminin alpha1LG domains and consequently their receptors have disparate functions in the neuromuscular system PMID:20657839
we analyze the lifespan of laminin alpha2 chain-deficient mice with transgenic overexpression of laminin alpha1 chain PMID:20544910
This first report of viable Lama1 mouse mutants emphasizes the importance of this gene in retinal development, and data suggest that hypomorphic mutations in human LAMA1 could lead to retinal disease. PMID:20048158
Exposure of cryptic domains in the alpha 1-chain of laminin-1 by elastase stimulates macrophages urokinase and matrix metalloproteinase-9 expression. PMID:11827968
Expression and distribution of laminin alpha1 in embryonic and adult mouse tissues PMID:11969289
mouse laminin alpha 1 gene has an upstream enhancer that defines its expression in parietal endoderm cells PMID:12519763
Data suggest that surface-exposed, conserved residues of the laminin gamma1 chain interact with the N-terminal domain of agrin via hydrophobic and ionic interactions. PMID:12554653
The absence of a alpha3(IV), alpha4(IV), alpha5(IV) network may stimulate reexpression of laminin-1 by Alport mouse endothelial cells and podocytes PMID:12631063
the first characterization of the Lama1 promoter; identification of a regulatory elements that may account for the expression pattern of the endogenous protein in the mouse intestine PMID:14634001
Mouse embryonic stem cells seeded on laminin formed hemispheric epithelial structures whose outermost layer terminally differentiated to an epithelium that resembled the visceral endoderm. PMID:15452149
Deletion of binding domains impair fetal development by preventing conversion of stem cells to polarized epithelium. PMID:15668394
The transient expression of laminin alpha1 may promote formation of sinusoids after partial hepatectomy. PMID:15777791
Grb2-binding to syntrophin is increased by addition of either laminin-1 or isolated laminin alpha1 globular domain modules LG4-5. LG4-5 sequences are the region of laminin responsible for signaling. Alpha-dystroglycan is the laminin-signaling receptor. PMID:16475793
suggest that LNalpha1 chain in part ameliorates the development of LNalpha2 chain deficient muscular dystrophy by retaining the binding sites for integrin alpha7Bbeta1D and alpha-dystroglycan, respectively PMID:16504180
analysis of structure and activities reveal differences in laminin G-like domain interactions that should enable dissection of biological roles of different laminin ligands PMID:17307732
Upregulation of Lama5 transcription and concentration of laminin alpha1 and alpha5 within Alport glomerular basement membrane thickenings contribute to abnormal permeabilities. PMID:17699809
define sites for the interaction of acetylcholinesterase and laminin and suggest that the interaction plays a role in cell adhesion PMID:18215127
The nonsulfated HNK-1 epitope on laminin-1 may regulate its binding and play a role in maintenance of the proper structure in the kidney basal lamina. PMID:18263654
Data examined expression of laminin-1, perlecan, tenascin-C, and CSPGs and found a coordinated pattern of expression of these cues in the olfactory pathway. These appear to restrict axons to the pathway while promoting axon outgrowth within. PMID:18570250
Our data suggest that doxycycline may provide a neuroprotection against global cerebral ischemia since it reduces perineuronal laminin degradation by inhibiting MMP-9 activity. PMID:19200854
Data suggest that laminin alpha1 domains LG4-5 provide an autocrine signal necessary for the complete differentiation of a functional visceral endoderm and vital signals for the polarization of the epiblast. PMID:19657675
Recovery of Lama1 expression or addition of exogenous laminin-111 to Shh(-/-);Gli3(-/-) embryos restores the myotomal basement membrane, demonstrating that laminin-111 is necessary and sufficient to initiate assembly of the myotomal basement membrane. PMID:19783738
Residues 'sinnnrwhsiyitrfgnmgs' promote adhesion in a heparin-sensitive but integrin-independent manner and binds approx. 155 kDa and 180 kDa cell surface proteins. PMID:9124607
Adhesion site formed by 'sinnnrwhsiyitrfgnmgs' is involved in formation of lung 'alveoli' in vitro. PMID:8132708