Recombinant Mouse Lamin-B1 (Lmnb1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Lmnb1

Uniprot NO.

P14733

Alternative Names

Lmnb1; Lamin-B1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-585

Target Protein Sequence

ATATPVQQQ RAGSRASAPA TPLSPTRLSR LQEKEELREL NDRLAVYIDK VRSLETENSA LQLQVTEREE VRGRELTGLK ALYETELADA RRALDDTARE RAKLQIELGK FKAEHDQLLL NYAKKESDLS GAQIKLREYE AALNSKDAAL ATALGDKKSL EGDLEDLKDQ IAQLEASLSA AKKQLADETL LKVDLENRCQ SLTEDLEFRK NMYEEEINET RRKHETRLVE VDSGRQIEYE YKLAQALHEM REQHDAQVRL YKEELEQTYH AKLENARLSS EMNTSTVNSA REELMESRMR IESLSSQLSN LQKESRACLE RIQELEDMLA KERDNSRRML SDREREMAEI RDQMQQQLSD YEQLLDVKLA LDMEISAYRK LLEGEEERLK LSPSPSSRVT VSRASSSRSV RTTRGKRKRV DVEESEASSS VSISHSASAT GNVCIEEIDV DGKFIRLKNT SEQDQPMGGW EMIRKIGDTS VSYKYTSRYV LKAGQTVTVW AANAGVTASP PTDLIWKNQN SWGTGEDVKV ILKNSQGEEV AQRSTVFKTT IPEEEEEEEE EPIGVAVEEE RFHQQGAPRA SNKSC
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.

Gene References into Functions

By using targeted knockout in olfactory epithelial stem cells in adult mice, we show that lamin B1 deficient neurons exhibit attenuated response to odour stimulation. This deficit can be explained by decreased expression of genes involved in mature neuron function, along with increased expression of genes atypical of the olfactory lineage. PMID:28425486
The parts of chromatin interact with nuclear lamina proteins like Lamin B1 and, therefore, can be identified in a given cell type by chromatin profiling of these proteins. PMID:29738692
Here we report that in primary mouse cortical neurons, LMNB1 overexpression reduces axonal outgrowth, whereas deficiency of endogenous Lmnb1 results in aberrant dendritic development. PMID:26510501
Analysis of lamin B1 expression in different regions of the brain in wild-type animals showed that the level of Lmnb1 transcript decreased significantly in an age-dependent manner. PMID:25343989
Data show that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other. PMID:25482116
lamins B1 and B2 have unique roles in the developing brain and increased production of one B-type lamin does not fully complement loss of the other. PMID:24672053
Lamin-B1 is required for organization of lamin-A/C and lamin-B2 in mouse embryonic stem cells and Lamin-B1 is required for organization of lamin-A/C and lamin-B2 in differentiated cells PMID:24523288
farnesylation of lamin B1--but not lamin B2--is crucial for brain development and for retaining chromatin within the bounds of the nuclear lamina during neuronal migration. PMID:23650370
lamin B1 overexpression mediates oligodendrocyte cell-autonomous neuropathology in adult-onset autosomal-dominant leukodystrophy. PMID:23676464
We conclude that lamin B1 is a modifier gene of major effect for Neural tube defects resulting from loss of Grhl3 function PMID:23166514
Lamin B1 is lost from primary human and murine cell strains when they are induced to senesce. PMID:22496421
Lamin B1 is essential for brain development and is required for the integrity of the nuclear lamina. PMID:21976703
study found that embryonic stem cells do not need any lamins for self-renewal and pluripotency; however, B-type lamins are required for proper organogenesis PMID:22116031
Absence of both Lmnb1 and Lmnb2 in keratinocytes has no effect on cell proliferation or the development of skin and hair. PMID:21659336
lamin B1 mutant mice provide evidence for a broad and nonredundant function of lamin B1 in mammalian development. PMID:15232008
Post-translationally processed lamin B1 has some control of gene expression as well as chromosome position. PMID:17312019
lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton. PMID:17488709
PLCbeta1 colocalizes and physically interacts with lamin B1. PMID:19028838
Sequestration of Oct-1 at the nuclear periphery by lamin B1 may be a mechanism by which the nuclear envelope can regulate gene expression and contribute to the cellular response to stress, development, and aging. PMID:19139261
lamin B1 and miR-23 have roles in the regulation of oligodendroglia development and myelin formation PMID:19259393