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Recombinant Mouse L-lactate dehydrogenase C chain (Ldhc)

Recombinant Mouse L-lactate dehydrogenase C chain (Ldhc)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Ldhc

Uniprot NO.

P00342

Alternative Names

Ldhc; Ldh-3; Ldh3L-lactate dehydrogenase C chain; LDH-C; EC 1.1.1.27; LDH testis subunit; LDH-X

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-332

Target Protein Sequence

STVKEQLIQ NLVPEDKLSR CKITVVGVGN VGMACAISIL LKGLADELAL VDADTNKLRG EALDLLHGSL FLSTPKIVFG KDYNVSANSK LVIITAGARM VSGETRLDLL QRNVAIMKAI VPGIVQNSPD CKIIIVTNPV DILTYVVWKI SGFPVGRVIG SGCNLDSARF RYLIGEKLGV NPTSCHGWVL GEHGDSSVPI WSGVNVAGVT LKSLNPAIGT DSDKEHWKNV HKQVVEGGYE VLNMKGYTSW AIGLSVTDLA RSILKNLKRV HPVTTLVKGF HGIKEEVFLS IPCVLGQSGI TDFVKVNMTA EEEGLLKKSA DTLWNMQKDL QL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Possible role in sperm motility.

Gene References into Functions

polymorphisms in the Ldhc gene control testis levels of S-2HG, and thereby epigenetics, across mammals PMID:27333189
Human LDHA was introduced as a transgene to Ldhc-null mice and rescued sperm function. PMID:23467744
C57BL/6 and 129S6 Ldhc KO mice were subfertile and infertile respectively. PMID:23486916
part of a complex involved in ATP homeostasis in sperm PMID:21565994
required for sperm to accomplish fertilization PMID:19875487
The high level of LDH-C(4) in postmeiotic cells results from mRNA and protein stability. PMID:14581510
Excess oxidative stress in selenium deficient mice affects the spermatogenic process with a reduction in mature sperm and in turn the LDH-X level. PMID:15273872
Ldh3 mRNA is transcribed in oocytes and cannot be detected in fertilized eggs. Ldh3 protein, however, persists to the blastocyst stage of embryonic development localizing mainly to the cortex region of oocytes, eggs, zygotes, and embryonic blastomeres. PMID:16582413
Simultaneous occupancy of the GC box and CRE sites in the core promoter is necessary for full expression of Ldhc in the testis. PMID:18057313
LDHC plays an essential role in maintenance of the processes of glycolysis and ATP production in the flagellum that are required for male fertility and sperm function. PMID:18367675