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Recombinant Mouse Keratin, type I cytoskeletal 19 (Krt19)

Recombinant Mouse Keratin, type I cytoskeletal 19 (Krt19)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Krt19

Uniprot NO.

P19001

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-403

Target Protein Sequence

MTSYSYRQTS AMSSFGGTGG GSVRIGSGGV FRAPSIHGGS GGRGVSVSST RFVTSSSGSY GGVRGGSFSG TLAVSDGLLS GNEKITMQNL NDRLASYLDK VRALEQANGE LEVKIRDWYQ KQGPGPSRDY NHYFKTIEDL RDKILGATID NSKIVLQIDN ARLAADDFRT KFETEHALRL SVEADINGLR RVLDELTLAR TDLEMQIESL KEELAYLKKN HEEEITALRS QVGGQVSVEV DSTPGVDLAK ILSEMRSQYE IMAEKNRKDA EATYLARIEE LNTQVAVHSE QIQISKTEVT DLRRTLQGLE IELQSQLSMK AALEGTLAET EARYGVQLSQ IQSVISGFEA QLSDVRADIE RQNQEYKQLM DIKSRLEQEI ATYRSLLEGQ EAHYNNLPTP KAI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.

Gene References into Functions

Cytokeratin-19 (CK-19)+ specific deletion of tumor suppressors p53 and Retinoblastoma (Rb) indicated that carcinomas at the injury site originates from cholangiocytes or liver progenitor cells. PMID:27323406
Demonstrate that K19 plays an important role in the ductular reaction that constitutes the basic regenerative response to chronic liver injury. PMID:26108453
Branched desmin-deficient (DKO) myofibers show significantly faster rates of calcium ion (Ca2+) clearance, with milder branching phenotype observed in DKO muscle suggesting that absence of keratin-19 corrects the defect created by absence of desmin alone. PMID:22592402
the structural response of each genotype is distinct, suggesting multiple mechanisms by which desmin and keratin influence the biomechanical properties of myofibers PMID:22287836
The expression of CK19 and EGFR in lymphatic metastasis of laryngeal carcinoma was higher than in controls. PMID:21845829
Results suggest that keratin filaments containing K19- and desmin-based intermediate filaments can play independent, complementary, or antagonistic roles in the physiology and morphology of fast-twitch skeletal muscle. PMID:21209367
a dual mechanism of how PDX-1 negatively regulates Krt19 ductal specific gene expression PMID:20808819
expression of nestin and cytokeratin 19 is a normal property of embryonic stem cells preceding differentiation into C-peptide/insulin-producing cells without any selection for nestin-positive phenotypes PMID:15602695
transduction of PDX1 in primary pancreatic ductal cells suppresses K19 expression, and short interfering RNA to PDX1 in Min6 insulinoma cells and results in the induction of normally undetectable K19 PMID:17056599
This is the first demonstration of a mammalian phenotype associated with a genetic perturbation of keratin 19. PMID:17971417
A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. PMID:18543299
Plastin 1 accumulates in the terminal web and interacts with keratin 19, possibly contributing to anchoring the rootlets to the keratin network. PMID:19321664