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Recombinant Mouse Keratin, type I cytoskeletal 14 (Krt14)

Recombinant Mouse Keratin, type I cytoskeletal 14 (Krt14)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Krt14

Purity

>85% (SDS-PAGE)

Target Names

Krt14

Uniprot NO.

Q61781

Alternative Names

Krt14; Krt1-14; Keratin; type I cytoskeletal 14; Cytokeratin-14; CK-14; Keratin-14; K14

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-484

Target Protein Sequence

MATCSRQFTS SSSMKGSCGI GGGSSRMSSI LAGGSCRAPS TYGGMSVTSS RFSSGGACGI GGGYGGSFSS SSFGGGLGSG FGGRFDGFGG GFGGGLGGGF GGGLGGGLGG GIGDGLLVGS EKVTMQNLND RLATYLDKVR ALEEANTELE VKIRDWYQRQ RPTEIKDYSP YFKTIEDLKS KILAATVDNA NVLLQIDNAR LAADDFRTKF ETEQSLRMSV EADINGLRRV LDELTLARAD LEMQIESLKE ELAYLKKNHE EEMASMRGQV GGDVNVEMDA APGVDLSRIL NEMRDQYEKM AEKNRKDAEE WFFSKTEELN REVATNSELV QSGKSEISEL RRTMQNLEIE LQSQLSMKAS LENNLEETKG RYCMQLAQIQ EMIGSVEEQL AQLRCEMEQQ NQEYKILLDV KTRLEQEIAT YRRLLEGEDA HLSSSQFSSS SQFSSGSQSS RDVTSTNRQI RTKVMDVHDG KVVSTHEQVL RTKN
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.

Gene References into Functions

Cumulatively, these data indicate that altered CK14 (high) and CK18 (low) expression is perhaps an early event in bladder cancer tumorigenesis in females at least and is characteristic of both urothelial superficial pre-neoplastic and neoplastic lesions. PMID:29350066
KRT14 is expressed in a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis. PMID:27320313
CDK1, Aurora-B, and Rho-kinase phosphorylate keratin 5/14. PMID:29518391
RA regulates Krt5 and Krt14 expression independently of stem cell character in developing salivary epithelium. The stem cell gene Kit is regulated inversely from Krt5/Krt14 by RA signaling. PMID:27884045
Analysis of K14 variants with single or multiple substitutions of cysteine residues points to a spatial and temporal hierarchy in how Cys-4/Cys-40 and Cys-367 regulate keratin assembly in vitro and filament dynamics in live keratinocytes PMID:26216883
Disulfide bonding is a novel and important mechanism regulating the assembly, intracellular organization, and dynamics of K14-containing intermediate filaments in skin keratinocytes. PMID:25869667
K14-VEGF transgenic mouse a valuable model to study novel immunotherapies for psoriasis PMID:21210341
autoantibodies in Scurfy mice and patients with IPEX target keratin 14 PMID:20147963
nipple connective tissue and its development: insights from the keratin 14-PTHrP mouse PMID:12049768
The keratin-14 IL-4 transgenic (Tg) mouse model of atopic dermatitis (AD) is characterized by skin infiltration of T cells, early up-regulation of T(h)2 cytokines and late surge of T(h)1 cytokines. PMID:16735375
These studies provide a potential mechanism by which deltaNp63 directly governs the expression of K14 in a keratinocyte-specific manner. PMID:17159913
Study describes the expression profile of claudins and keratin markers in the accelerated epidermal permeability barrier formation of K14-CaSR transgenic mice during development as compared to the wild type from E12.5 to newborn stages. PMID:17182288
DeltaNp63 alone can restore the expression of the basal keratins and reinitiate the failed epidermal differentiation program in the skin of p63 null animals. PMID:19461998

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Intermediate filament family

Tissue Specificity

Expressed in the corneal epithelium (at protein level). Expressed in the epithelial basal layer in the tail epidermis. Expressed in the parabasal cell row, basal cell layer, and suprabasal epithelial layer of the tongue.

Database Links

UNIGENE: Mm.439898

KEGG: mmu:16664

STRING: 10090.ENSMUSP00000007272

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