Recombinant Mouse Kelch-like protein 6 (Klhl6)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Klhl6

Purity

>85% (SDS-PAGE)

Target Names

Klhl6

Uniprot NO.

Q6V595

Alternative Names

Klhl6Kelch-like protein 6

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-619

Target Protein Sequence

MAGQRGACTM SDVVERSLEG PLALTTDKSS QKRGDLVEIL TGEKVKFDDT RLSLILQNGL ETLREENALT DVILCVDVQE FSCHRVVLAA ASNYFRAMFC NDLKEKYEKR IIIKGVDAET MHTLLVYTYT SKALITKQNV QRVLEAANLF QFLQLVDACA SFLTEALNPE NCIGILRLAD THSLDSLKMQ VQSYIIQNFV QILNSEEFLE LPVDTLYHIL RSDDLCVTEE AQVFETVMSW VRHKQSERLC LLPCVLENVR LPLLDPWYFV EMVEADPLIR QCPEVFPLLQ EARMYHLSGN EIISERTKPR MHEFQSEVFM IIGGCTKDER FVAEVTCLDP LRRSRLEVAK LPLTEHELES ENKKWVEFAC VTLKNEVYIS GGKETQHDVW KYNSSINKWI QIEYLNIGRW RHKMVVLGGK VYVLGGFDGL QRINNVETYD PFHNCWSEAA PLHVHVSSFA ATSHKKKLYV IGGGPNGKLA TDKTQCYDPS TNKWVLKSAM PVEAKCINAV SFQDHIYVVG GAMRALYAYS PLEDSWCLVT QLSHERASCG IAPCNNKLYI TGGRDEKNEV IATVLCWDPE AQKLTEECVL PRGVSHHGSV TIRKSYTHIR RVVPGAVSV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Gene References into Functions

report that KLHL6, which is recurrently mutated in B cell lymphomas, is an off-target of the normal somatic hypermutation process taking place in germinal center (GC) B cells leaving open whether, despite the lack of impact of Klhl6 deficiency on GC B cell expansion, mutants could contribute to the oncogenic process PMID:28807996

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Tissue Specificity

Expressed in embryonic blood vessel endothelial cells but not in the vasculature of adult organs. In adults, detected at high levels in hematopoietic and lymphoid organs.

Database Links

UNIGENE: Mm.86699

KEGG: mmu:239743

STRING: 10090.ENSMUSP00000053023

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