Home
Product
Protein
Recombinant Proteins
Recombinant Mouse Junctional adhesion molecule B (Jam2), partial

Recombinant Mouse Junctional adhesion molecule B (Jam2), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

Jam2

Purity

>85% (SDS-PAGE)

Target Names

Jam2

Uniprot NO.

Q9JI59

Alternative Names

Jam2; VejamJunctional adhesion molecule B; JAM-B; Junctional adhesion molecule 2; JAM-2; Vascular endothelial junction-associated molecule; VE-JAM; CD antigen CD322

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes. Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3. Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium. Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1. Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons. During myogenesis, it is involved in myocyte fusion. May also play a role in angiogenesis.

Gene References into Functions

JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter. PMID:27111582
JAM-B is an as yet underappreciated trophoblast lineage-specific protein, which is modulated via the progesterone receptor and shows unique strain-specific kinetics. PMID:26914234
identify neuronal junction adhesion molecule 2 (JAM2) as an inhibitory myelin-guidance molecule. PMID:27499083
JAM-B expression was detected in de novo-formed blood vessels of tumors. PMID:25911611
Function of Jam-B/Jam-C interaction in homing and mobilization of human and mouse hematopoietic stem and progenitor cells. PMID:24357068
Data show that junctional adhesion molecule-B (JAM-B) expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with junctional adhesion molecule-C (JAM-C) on tumor cells. PMID:23068611
Jam2 has a role in the interaction between hatched blastocyst and receptive uterus. PMID:22511936
JAM-B is an active player in the maintenance of the bone marrow stromal microenvironment. PMID:21868569
promotes lymphocyte transendothelial migration PMID:12239159
Results suggest a role for junctional adhesion molecule-2 (JAM-2) in facilitating transmigration in endothelial cells. PMID:12476045
Interactions with JAM-B and -C are essential for development of cutaneous inflammation. PMID:16297198
These results demonstrate that Jam-B is dispensable for normal mouse development and stem cell identity in embryonic, neural, and hematopoietic stem cells. PMID:16914739
JAM-B identifies a unique population of RGCs in which structure corresponds remarkably to function PMID:18368118

Hide All

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cell junction. Cell junction, tight junction.

Protein Families

Immunoglobulin superfamily

Tissue Specificity

Expressed by bone marrow stromal cells (at protein level). Expressed in skin (at protein level). Expressed in testis by Sertoli cells (at protein level). Expressed by dorsal root ganglion and spinal cord neurons.

Database Links

UNIGENE: Mm.41758

KEGG: mmu:67374

STRING: 10090.ENSMUSP00000109833

Promotions