Recombinant Mouse Interferon lambda-3 (Ifnl3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Il28b

Purity

>85% (SDS-PAGE)

Target Names

Ifnl3

Uniprot NO.

Q8CGK6

Alternative Names

Ifnl3; Il28; Il28bInterferon lambda-3; IFN-lambda-3; Interleukin-28B; IL-28B

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

20-193

Target Protein Sequence

D PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKGAIEK RLLEKDMRCS SHLISRAWDL KQLQVQERPK ALQAEVALTL KVWENINDSA LTTILGQPLH TLSHIHSQLQ TCTQLQATAE PKPPSRRLSR WLHRLQEAQS KETPGCLEDS VTSNLFQLLL RDLKCVASGD QCV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene References into Functions

results suggest that IL-28B induces more mature NK cells to defend against viruses, in addition to its direct antiviral activity PMID:28637903
IL-28B down-regulates Tregs following subunit vaccine ESAT6-Ag85B-Mpt64(190-198)-Mtb8.4-HspX vaccination but does not improve the protective immune responses. PMID:26521300
the role of IFN-lambda in IDO regulation was investigated after influenza infection of respiratory epithelial cells. PMID:25756191
Acritical role of IL-28 cytokines is in controlling T cell responses in vivo through the modulation of lung CD11c(+) DC function in experimental allergic asthma. PMID:21538995
IFN-lambda is involved in development and maintenance of oral tolerance in the intestines of mice. PMID:21569774
IFN-alpha, IFN-beta, and IFN-gamma were observed in the anterior segment of injected eyes through 72 hours and mRNA levels of IFN-beta and IFN-gamma were increased in virus-infected eyes 48 to 120 hours after herpes simplex infection PMID:21345992
intranasal influenza A virus infection leads to the robust type III IFN induction in the lungs of both WT and IFNAR-/- mice PMID:20739515
IFN-lambda contributes to the control of viral infections in epithelial cells of both respiratory and gastrointestinal tracts. PMID:20335250
IFN-lambda inhibits HBV replication and blocks replication of a subgenomic and a full-length genomic HCV replicon PMID:15731279
IL-28A emerges as a key regulatory cytokine with pathogenic function in T-cell-mediated liver injury PMID:17241885
Type III interferon/IL-28 targets a specific subset of cells and contributes to the antiviral response evoked by Toll-like receptors, largely mediated by inducing an antiviral state in epithelial cells. PMID:18250457
IFN-lambda contributes to inborn resistance against viral pathogens infecting the lung but not the liver PMID:18787692
IL-28B can induce 100% protection from mortality after a lethal influenza challenge PMID:19304955