Recombinant Mouse Interleukin-28A (Il28a)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Il28a

Purity

>85% (SDS-PAGE)

Target Names

Ifnl2

Uniprot NO.

Q4VK74

Alternative Names

Ifnl2; Il28aInterferon lambda-2; IFN-lambda-2; Interleukin-28A; IL-28A

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

20-193

Target Protein Sequence

D PVPRATRLPV EAKDCHIAQF KSLSPKELQA FKKAKDAIEK RLLEKDLRCS SHLFPRAWDL KQLQVQERPK ALQAEVALTL KVWENMTDSA LATILGQPLH TLSHIHSQLQ TCTQLQATAE PRSPSRRLSR WLHRLQEAQS KETPGCLEAS VTSNLFRLLT RDLKCVANGD QCV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Gene References into Functions

Fetuses lacking IFN-lambda signaling had increased Zika virus replication in the placenta, and treatment of pregnant mice with IFN-lambda2 reduced ZIKV infection. PMID:28910635
IFN-lambda2 and its receptor may become targets of anti-cancer therapy. PMID:29151074
IL28 controls proliferation of IECs in mice with colitis and accelerates mucosal healing by activating STAT1. PMID:28342759
IL-28A is capable of exacerbating a T-cell-mediated autoimmune disease. PMID:25138017
Data indicate that rotavirus infection induces production of interferon-lambda (IFN-lambda) and interleukin 22 (IL-22) by intestinal epithelial cells. PMID:26006013
IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b-expressing neutrophils PMID:25941255
The level of IFN-lambda2 was significantly increased in the infected cells treated with with shRNAs against influenza a virus M1. PMID:26104331
IFN-lambda2 limits VSV replication in the mouse lung. PMID:25008938