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Recombinant Mouse Interleukin-28 receptor subunit alpha (Il28ra), partial

Recombinant Mouse Interleukin-28 receptor subunit alpha (Il28ra), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Il28ra

Purity

>85% (SDS-PAGE)

Target Names

Ifnlr1

Uniprot NO.

Q8CGK5

Alternative Names

Ifnlr1; Il28ra; Interferon lambda receptor 1; IFN-lambda R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; CRF2-12; Interleukin-28 receptor subunit alpha; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.

Gene References into Functions

Ifnlr1 is expressed in the epithelial fraction along the length of the gastrointestinal tract and is essential for induction of IFN-lambda-mediated sterilizing innate immunity to norovirus. PMID:28077655
interferon-lambda has a role in noncanonical signaling through IFNLR1, which tightens the blood-brain barrier and restricts viral neuroinvasion and pathogenesis PMID:25904743
Rotavirus infection induces production of IFN-lambda by IECs and of IL-22 by ILC3 cells. PMID:26006013
IL-28R is essential for optimal in vivo activity of natural killer cells PMID:25901316