Recombinant Mouse Interleukin-24 (Il24)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Il24

Purity

>85% (SDS-PAGE)

Target Names

Il24

Uniprot NO.

Q925S4

Alternative Names

Il24; Mda7Interleukin-24; IL-24; IL-4-induced secreted protein; Melanoma differentiation-associated gene 7 protein; MDA-7; Th2-specific cytokine FISP

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

27-181

Target Protein Sequence

QEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Gene References into Functions

our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) . PMID:28125663
this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity PMID:28330899
Loss of IL-24 expression is associated with breast cancer. PMID:26460950
A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB was triggered by TNFR1-dependent upregulation of interleukin-24 & activation of STAT3 signaling in keratinocytes. PMID:24211183
IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS) production through the regulation of mitochondrial ROS production and expression of antioxidant enzymes PMID:23052189
Secretory mIL-24 did not induce the expression of the IL-6, TNF-alpha or IFN-gamma gene in spleen cells PMID:22475191
T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 and c-Jun transcription factors at the transcriptional level. PMID:21357535
induction of Il24 by oncogenes may support tumor growth at the early stages of cancer PMID:15326486
Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 PMID:18483274
the novel splicing variant of IL24, FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo PMID:18708357
Data demonstrated that IL-24 predominately stimulated neutrophils to produce IFN-gamma and IL-12, subsequently activating CD8+ T cells both in vivo and in vitro. PMID:19830736