Recombinant Mouse Interleukin-18 receptor 1 (Il18r1), partial

1. IL-18R-immunoreactive neurons were present in layers II, III and VI of the retrosplenial cortex in 2-week-old mice, whereas they were sparsely observed in only layer III in 3-week-old mice. No IL-18R-ir neurons were present in 4- and 5-week-old mice. In older than 6-week-old mice, many IL-18R-ir neurons were present in layers V and VI. PMID:29681594
2. IL-18Ralpha-mediated signaling pathway plays critical role in CD4+ T cells and antigen-presenting cells response in LPS-induced acute kidney injury. PMID:29261164
3. These findings establish the T-cell intrinsic IL-18R/MyD88 pathway as a crucial element for induction of cognate Th1 responses against an important human pathogen. PMID:28895840
4. Despite these findings however, IL-18Ralpha-deficient CD4(+) T cells induced comparable intestinal pathology to WT CD4(+) T cells. These findings suggest that IL-18-dependent cytokine induced activation of CD4(+) T cells is not critical for the development of T-cell-mediated colitis. PMID:27062602
5. strong evidence that IL-18 and IL18Ralpha have important functions in the pathogenesis of allergic asthma PMID:26561030
6. IL-37 requires IL-18Ralpha and SIGIRR/IL-1R8 to diminish allergic airway inflammation in mice PMID:25557042
7. IL-37 requires the receptors IL-18Ralpha and IL-1R8 to carry out its multifaceted anti-inflammatory program upon innate signal transduction. PMID:25729923
8. data reveal that IL-18Ralpha has an anti-inflammatory effect in IRI-induced AKI. Above all, IL-18 enhanced the inflammatory mechanisms and the apoptosis of TECs through the Fas/FasL pathway by blocking IL-18Ralpha PMID:25329004
9. compared IL-18Ralpha knockout with wild-type mice in cisplatin-induced acute kidney injury and found deteriorated kidney function, tubular damage, and increased accumulation of leukocytes PMID:22673883
10. The presence or absence of IL-18 receptor alpha signals governs pathogenic versus protective immunity in a model of Ehrlichia-induced immunopathology. PMID:21715688
11. These data suggest a role for IL-1F family members in psoriasis. PMID:20833839
12. review of structure, function and tissue distribution of IL-18R [review] PMID:15323361
13. IL-18R alpha and IL-17-producing T helper cells are required for autoimmune central nervous system inflammation. PMID:16906165
14. IL-18Ralpha gene expression is regulated by estrogen and progesterone and that the uterine IL-18 system is involved in the regulation of uterine functions in a paracrine manner PMID:17062984
15. islets from mice deficient in IL-18 receptor alpha chain (IL-18R) exhibited rapid graft failure PMID:17075045
16. IL-18 signaling in BSA nephritis mice significantly alleviates immune complex renal disorder; this may thus represent a novel approach to the treatment of patients with immune complex nephritis. PMID:18462998
17. Ectopic expression of GATA-3 in differentiated Th1 cells repressed Il18r1 mRNA and surface expression of IL-18Ralpha. PMID:18714006
18. The authors found that signaling through the IL-18 receptor is not required for normal T-cell response kinetics and survival of immunized mice challenged with a lethal L. monocytogenes infection. PMID:19223481
19. a role for SOCS1 and -3 in the seemingly paradoxical hyperresponsive state in cells deficient in IL-18Ralpha, supporting the concept that IL-18Ralpha participates in both pro- and anti-inflammatory responses PMID:19592492

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UNIGENE: Mm.253664

KEGG: mmu:16182

STRING: 10090.ENSMUSP00000085298