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Recombinant Mouse Interleukin-17 receptor E (Il17re), partial

Recombinant Mouse Interleukin-17 receptor E (Il17re), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Il17re

Purity

>85% (SDS-PAGE)

Target Names

Il17re

Uniprot NO.

Q8BH06

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Specific functional receptor for IL17C, signaling through the NF-kappa-B and MAPK pathways. Requires TRAF3IP2 /ACT1 for signaling. Crucial regulator in innate immunity to bacterial pathogens, such as Citrobacter rodentium. Isoform 4 and isoform 5 may be either cytoplasmic inactive or dominant active forms. Isoform 2 and isoform 3 may act as soluble decoy receptors.

Gene References into Functions

IL-17C and IL-17RE are dispensable for immunity to candidiasis PMID:25849644
IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens. PMID:21993849
IL-17C-IL-17RE induced the expression of a nuclear IkappaB family member, IkappaBzeta, in Th17 cells to potentiate the Th17 cell response PMID:21982598

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Cytoplasm.; [Isoform 5]: Cytoplasm.

Tissue Specificity

Predominantly expressed in mucosal tissues, including trachea, lung, kidney and stomach. Highly expressed in colon epithelial cells. Also expressed in testis. Low expression, if any, in heart, liver, spleen, or brain. Among CD4 T-helper cells, expressed a

Database Links

UNIGENE: Mm.131781

KEGG: mmu:57890

STRING: 10090.ENSMUSP00000062103

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