Recombinant Mouse Interleukin-12 receptor subunit beta-1 (Il12rb1), partial

1. the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12. PMID:25404030
2. Although they share a common subunit, IL-23 and IL-12 receptors are not expressed on the same cell populations. PMID:24586521
3. IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection PMID:22907814
4. IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40)2 dependent mechanism. PMID:21669537
5. IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis. PMID:20212068
6. IL-12R beta 1 deficiency results in decreased viral replication and inflammation following coxsackievirus B3-induced myocarditis, decreasing IL-1 beta and IL-18 in the heart. PMID:12707353
7. The binding domain in the IL-12 receptor beta 1 cytoplasmic region has been mapped to sphingosine kinase 2. PMID:12874225
8. Expression of the IL-12 beta 1 receptor is upregulated in both microglia and splenic macrophages. PMID:14568135
9. IL-12 receptor beta 1 subunit plays an essential role in the activation and differentiation of Th1-type myelin oligodendrocyte glycoprotein (MOG)-specific autoreactive T cells in vivo. PMID:14568921
10. IL-12 receptor beta 1 (Rbeta1) mediates IL-12 p40 homodimer (p80)-dependent macrophage chemotaxis and inhibition of the p80-Rbeta1 interaction, a novel anti-inflammatory strategy to manipulate inflammation associated with respiratory viral infection. PMID:14662893
11. IL-15 induces chromatin remodeling of the IL12RB1 gene promoter, increasing IL12RB1 mRNA expression in synergy with IFN-gamma through the recruitment of PU.1 and IRF3. PMID:15345588
12. Male and female mice deficient in IL-12Rbeta1 had decreased inflammation and viral replication in the heart, indicating that IL-12Rbeta1 signaling increases myocarditis in both sexes. PMID:16949558
13. This study delineates a new role of IL-12R beta 1 and IL-12R beta 2 for the expression of iNOS and production of NO in microglia that may participate in the pathogenesis of neuroinflammatory diseases. PMID:19306359
14. Data show that the loss of IL-12R engagement does not appear to alter T-cell expansion but leads to their accumulation in secondary lymphoid organs. PMID:19544494
15. Results show that direct IL-12 receptor signaling to CD8(+) T cells determines the cell fate decision between short-lived effector cells and memory precursor effector cells, which is dependent on pathogen-induced local cytokine milieu. PMID:19548244

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UNIGENE: Mm.731

KEGG: mmu:16161

STRING: 10090.ENSMUSP00000000808