Recombinant Mouse Homeobox protein Hox-B1 (Hoxb1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hoxb1

Uniprot NO.

P17919

Alternative Names

Hoxb1; Hox-2.9; Hoxb-1Homeobox protein Hox-B1; Homeobox protein Hox-2.9

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-297

Target Protein Sequence

MDYNRMSSFL EYPLCNRGPS AYSAPTSFPP CSAPAVDSYA GESRYGGGLP SSALQQNSGY PVQQPPSSLG VSFPSPAPSG YAPAACNPSY GPSQYYSVGQ SEGDGSYFHP SSYGAQLGGL PDSYGAGGVG SGPYPPPQPP YGTEQTATFA SAYDLLSEDK ESPCSSEPST LTPRTFDWMK VKRNPPKTAK VSELGLGAPG GLRTNFTTRQ LTELEKEFHF NKYLSRARRV EIAATLELNE TQVKIWFQNR RMKQKKRERE GGRMPAGPPG CPKEAAGDAS DQSACTSPEA SPSSITS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures.

Gene References into Functions

Hoxa1 and Hoxb1 have diverged in function through either sub- or neo-functionalization and that the HoxA1 and HoxB1 proteins are not mutually interchangeable when expressed from the Hoxa1 locus PMID:28380068
provide a comprehensive account of the developmental role of Hoxb1 in patterning the vestibular system and evidence for a remarkable developmental plasticity in the descending control of reflex limb movements PMID:26730404
Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. PMID:26284287
Hoxb1 is required for the anterior-posterior identity of precursors that contribute to the lateral vestibular nucleus. PMID:22485187
The results of this study show that ES neural differentiation and inducible Hox gene expression can be used as a sensitive model system to systematically identify Hox novel target genes. PMID:21637844
identified a novel Hoxb3 binding site S3 on the Hoxb1 locus and confirmed protein binding to this site in hindbrain tissues from the Hoxb3(Tg) mutant PMID:21320481
Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice PMID:11891985
Hoxb1 has a role in neural crest development into glia of the peripheral nervous system PMID:12815623
Results suggest that tissues are primed to express Hox genes, such as Hoxb1, early in gastrulation, concomitant with primitive streak formation and extension, and that Hox gene inducibility is transferred by cell to cell signalling. PMID:12835396
the development and maintenance of the VIIth cranial nerve is dependent upon Hoxb1, both in the neural crest-derived glia and in the facial branchiomotor neurons PMID:15198977
the activity of the Hoxb1 autoregulatory enhancer depends upon multiple Prep1-Pbx1 (PM1, PM2, and PM3) and Pbx1-Hoxb1 (R1 and R3) binding sites that cooperate to modulate and spatially restrict the expression of Hoxb1 in r4 rhombomere PMID:16166636
The mice expressing the Hox-B1 protein from the Hoxa1 locus, and vice versa, are essentially normal. PMID:16890163
Hoxb1 contains the cis-acting elements sufficient to initiate ectopic local nuclear reorganisation and chromatin decondensation and to break Hoxd colinearity in the primitive streak region of the early embryo. PMID:18252796
Hoxb1 controls cell fate specification and proliferative capacity of neural stem and progenitor cells PMID:18499896