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Recombinant Mouse Histone-lysine N-methyltransferase SETD7 (Setd7)

Recombinant Mouse Histone-lysine N-methyltransferase SETD7 (Setd7)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Setd7

Purity

>85% (SDS-PAGE)

Target Names

Setd7

Uniprot NO.

Q8VHL1

Alternative Names

Setd7; Kiaa1717; Set7; Set9; Histone-lysine N-methyltransferase SETD7; EC 2.1.1.-; Histone H3-K4 methyltransferase SETD7; H3-K4-HMTase SETD7; SET domain-containing protein 7; SET7/9

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-366

Target Protein Sequence

MDSDDEVVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDS DGRLIFKGQY KDNNRHGVCW IHYPDGGSLV GEVNEDGEMT GEKIAYVYPD QRTALYGKFI DGEMLEGKLA TLMATEEGRP HFEVTSGSSV YHFDKSTSSC ISSDALLPDP YESERVYVAD SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCVYDLFVH PRFGPIKCIR TLRAVEAEEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.

Gene References into Functions

Murine peritoneal fibrosis was induced by intraperitoneal injection of methylglyoxal (MGO). SET7/9 expression was elevated in MGO-injected mice. PMID:29723250
spinal SET7/9 may contribute to the maintenance of CIBP PMID:28557056
the methyltransferase Set9 potentiates TGF-beta signaling by targeting Smad7, an inhibitory downstream effector. PMID:27292644
SETD7 plays an important role in intestinal epithelial cell (IEC) biology during infection. PMID:27598373
We observe Set7-mediated modification of serum response factor (SRF) and mono-methylation of histone H4 lysine 4 (H3K4me1) regulate gene expression. We conclude the broad substrate specificity of Set7 serves to control key transcriptional networks in embryonic stem cells. PMID:27439711
SETD7 is required for Wnt-driven intestinal tumorigenesis and regeneration. SETD7-dependent methylation of YAP facilitates Wnt-induced nuclear accumulation of beta-catenin. PMID:27046831
SET7/9 regulates Nos2 expression through methylation of H3K4 in beta cells. PMID:25995453
Data indicate that the ability of transcription factor Pdx1 to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9. PMID:25713082
study found that Set7 is a modifier of the Hippo pathway. Mice that lack Set7 have a larger progenitor compartment in the intestine, coinciding with increased expression of Yes-associated protein target genes. PMID:23850191
The response to hyperglycemia in vascular endothelial cells involves Set7 mediated changes in chromatin remodeling and gene expression. PMID:22403242
Set7/9-mediated methylation of p53 does not represent a major regulatory event and does not appreciably control p53 activity in vivo. PMID:21855805
Set7/9 is dispensable for p53 function in the mouse. PMID:21855806
Define a biological function for Set7 in muscle differentiation and provide a molecular mechanism by which Set7 modulates myogenic transcription factors during muscle differentiation. PMID:21859860
Pdx1-dependent Set7/9 expression may be crucial to enhancing chromatin accessibility and transcription of beta-cell genes. PMID:21099283
Methylation of p53 by Set7 mediates p53 acetylation and activity in vivo. PMID:18280244
a novel role for SET7/9 in inflammation and diabetes. PMID:18650421
Data conclude that Set7/9 is required for normal beta-cell function, likely through the maintenance of euchromatin structure at genes necessary for glucose-stimulated insulin secretion. PMID:18984737
ASCOM-MLL3 and ASCOM-MLL4 likely function as crucial but redundant H3K4MT complexes for PPARgamma-dependent adipogenesis PMID:19047629