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Recombinant Mouse Hepatoma-derived growth factor (Hdgf)

Recombinant Mouse Hepatoma-derived growth factor (Hdgf)

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Hdgf

Uniprot NO.

P51859

Species

Mus musculus (Mouse)

Source

E.coli

Expression Region

1-237

Target Protein Sequence

MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY QSSQKKSCAA EPEVEPEAHE GDGDKKGSAE GSSDEEGKLV IDEPAKEKNE KGTLKRRAGD VLEDSPKRPK ESGDHEEEDK EIAALEGERP LPVEVEKNST PSEPDSGQGP PAEEEEGEEE AAKEEAEAQG VRDHESL
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Acts as a transcriptional repressor. Has mitogenic activity for fibroblasts. Heparin-binding protein.

Gene References into Functions

liver cancer cell-derived HDGF can induce Foxp3(+) T cells; the latter has immune suppressor functions on CD8(+) T cell activities PMID:25569374
Up-regulation of hepatoma-derived growth factor facilities tumor progression in malignant melanoma. PMID:23536873
HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue. PMID:22014102
HDGF exploits the innate properties of both cell surface heparan sulfates and membrane receptor via the HATH domain to affect related cell signalling processes PMID:20964630
HDGF plays a pro-fibrogenic role during liver fibrosis in mice through activation of TGF-beta pathway. PMID:19913322
Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus PMID:11751870
Hepatoma-derived growth factor helps regulate the hepatocyte proliferation in liver development. PMID:12447878
Increased HDGF expression is correlated with disease progression of hepatocellular carcinoma and represent a specific prognostic factor in patient with liver cancer. PMID:14508832
we investigated the role of HDGF in tumorigenesis and elucidated the mechanism of action. PMID:14662017
HDGF is a novel type of neurotrophic factor harbored in the nucleus and it functions in an autocrine manner. PMID:15140875
hepatoma-derived growth factor has roles in development and intestinal neoplasms PMID:15604097
HDGF is a novel trophic factor for motor neurons and it might play a protective role against motor neuron degeneration. PMID:16987236
The lack of obvious biochemical and morphological phenotypes in HDGF-deficient mice demonstrates that in vivo HDGF is dispensable for normal development in mice. PMID:18570251

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Subcellular Location

Nucleus. Cytoplasm. Secreted, extracellular exosome.

Protein Families

HDGF family

Tissue Specificity

Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.

Database Links

UNIGENE: Mm.292208

KEGG: mmu:15191

STRING: 10090.ENSMUSP00000005017

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