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Recombinant Mouse Guanine nucleotide exchange factor VAV2 (Vav2), partial

Recombinant Mouse Guanine nucleotide exchange factor VAV2 (Vav2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Vav2

Purity

>85% (SDS-PAGE)

Target Names

Vav2

Uniprot NO.

Q60992

Alternative Names

Vav2; Guanine nucleotide exchange factor VAV2; VAV-2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-868

Target Protein Sequence

MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI AQSKGIRPFP SEETAENDDD VYRSLEELAD EHDLGEDIYD CVPCEDEGDD IYEDIIKVEV QQPMKMGMTE DDKRSCCLLE IQETEAKYYR TLEDIEKNYM GPLRLVLSPA DMAAVFINLE DLIKVHHSFL RAIDVSMMAG GSTLAKVFLE FKERLLIYGE YCSHMEHAQS TLNQLLASRE DFRQKVEECT LRVQDGKFKL QDLLVVPMQR VLKYHLLLKE LLSHSADRPE RQQLKEALEA MQDLAMYINE VKRDKETLKK ISEFQCSIEN LQVKLEEFGR PKIDGELKVR SIVNHTKQDR YLFLFDKVVI VCKRKGYSYE LKEVIELLFH KMTDDPMHNK DIKKWSYGFY LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC KMFLRGTFYQ GYLCTRCGVG AHKECLEVIP PCKMSSPADV DAPGAGPGPK MVAVQNYHGN PAPPGKPVLT FQTGDVIELL RGDPDSPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPTGR PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI KVVEKDSWIH ITEAKKFESL LELVEYYQCH SLKESFKQLD TTLKFPYKSR ERTTSRASSR SPASCASYNF SFLSPQGLSF APQAPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG DVVKIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGVQ
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly.

Gene References into Functions

reduction of VAV2 in absence of CUX1 was associated with a significant decrease of RAC1 activity in response to epithelial wounding. Our results identify a novel pathway by which CUX1 regulates normal intestinal epithelial cell restitution PMID:28893557
This inhibitory action of Vav2 shRNA on Hcys-induced podocyte injury was associated with reduction of Rac1 activity and ROS production. These results suggest that elevated Hcys levels activate Vav2 and thereby increase NOX activity leading to ROS production, which triggers NLRP3 inflammasome activation, podocyte dysfunction and glomerular injury. PMID:28193546
Results show that Vav2 and Rac1 are commonly involved in blood pressure regulation. PMID:25288640
Data demonstrate that the co-expression of the exchange factors Vav2 and Vav3 is critical for the development of this tumor type. PMID:23935450
Vav2 and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery. PMID:22596354
The results indicate that ADIP plays an essential role in PDGF-induced cell movement by interacting with afadin and Vav2 and regulating the activation of Rac. PMID:22027834
Cbl ubiquitin ligase plays a critical role in the maintenance of AJs and suppression of cell migration through down-regulation of EGFR-Vav2 signaling. PMID:20940296
Data show that Vav2/Vav3-deficient mice show early onset of iridocorneal angle changes and elevated intraocular pressure, with subsequent selective loss of retinal ganglion cells and optic nerve head cupping, which are the hallmarks of glaucoma. PMID:20140222
Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells. PMID:20038798
does not contribute to platelet aggregation by CRP and thrombin, and is not required for regulation of phospholipase C. PMID:12411320
Vav2 is a GEF responsible for the nectin-induced, c-Src-, and Cdc42-mediated activation of Rac PMID:15485841
Vav2-deficient macrophages display a high level of constitutive membrane ruffling. PMID:16137676
These results indicate that Vav2 plays crucial roles in the maintenance of cardiovascular homeostasis in mice. PMID:17202406
Vav2 regulates the Rac1 activity associated with the binding step of collagen phagocytosis. PMID:18434624
Data suggest that Vav2/3 guanine nucleotide exchange factors play a critical role in host-mediated tumor progression and angiogenesis, particularly in tumor endothelium. PMID:19435813