Recombinant Mouse Guanine nucleotide-binding protein subunit alpha-11 (Gna11)

1. Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone and exercise PMID:27300035
2. results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury. PMID:27811142
3. the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq/11-dependent fashion. PMID:26843449
4. In Galpha11-knock-out mice there is a decreased heart rate and increased ejection fraction. PMID:26476043
5. ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells. PMID:26208885
6. the conditional deletion of Galphaq/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition. PMID:25495873
7. Loss of gq/11 genes does not abolish melanopsin phototransduction. PMID:24870805
8. Mediated by lysophosphatidylinositol, Galpha(q/11) is activated in sensory neurons. PMID:23973358
9. Myocytes from the Galpha(q) and/or Galpha(11) KO mice displayed genuine alterations in the action potentials, membrane capacitance, membrane currents, and Ca(2+) handling PMID:22562663
10. Report differential expression of protein kinase C isoforms in coronary arteries of diabetic mice lacking Gna11. PMID:21190563
11. GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Galpha(q/11) and beta-arrestin-dependent manner. PMID:20886089
12. a signaling pathway via the G(q)-proteins, G(alpha)(11) and G(alpha)(q), that could link increased neurohumoral stimulation in diabetes with defective RyR2 channel function by regulating protein expression of FKBP12.6, annexin A7, and sorcin. PMID:20372981
13. Galpha(q) and Galpha(11) proteins serve as the intracellular mediators of endothelin-1 signaling in the pharyngeal arch mesenchyme PMID:12648486
14. Our findings suggest an expression level-dependent action of Galpha(q) and Galpha11 for Purkinje cell signaling and assign specific roles of these two G(q) isoforms for motor coordination PMID:15175381
15. G(q/11) signaling is indispensable to the neuronal circuit that connects the perception of pup-related stimuli to the initiation of maternal behavior PMID:15340067
16. G(q)/G(11)- but not G(12)/G(13)-mediated signaling processes mediate ET-1/ET(A)-dependent development of the cephalic neural crest. PMID:15936338
17. both Gq and G11 have critical roles in mediating inhibition of PTH secretion by extracellular Ca2+ PMID:16988000
18. lysophospholipids regulate integrin-mediated adhesion of splenic B cells to ICAM-1 through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11) PMID:17023430

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UNIGENE: Mm.260925

KEGG: mmu:14672

STRING: 10090.ENSMUSP00000043190