Recombinant Mouse Glutathione S-transferase P 1 (Gstp1)

1. Expression of both wild-type and catalytically-inactive Y7F mutant GSTP significantly attenuated LPS- or IKKbeta-induced production of GM-CSF. These studies indicate a complex role for GSTP in modulating NF-kappaB, which may involve S-glutathionylation of IKK proteins, and interaction with NF-kappaB family members. PMID:27058114
2. GSTP can exert redox regulation in the oxidative ER environment and indicate that, within the ER, GSTP influences the cellular consequences of the UPR through S-glutathionylation of a series of key interrelated proteins. Antioxid. PMID:26838680
3. our study reveals the novel role of GSTP1 in regulation of iNOS by affecting S-nitrosylation, dimerization, and stability. PMID:26361746
4. These observed differences contribute to our understanding of how genetic ablation of GSTP causes different levels of myeloproliferation and migration [corrected] PMID:25216273
5. GSTP1 expression in retina increases with developmental age in mice and accompanies murine retinal maturation. PMID:24664677
6. GSTP knock-out mice display decreased ubiquitination capacity and overall increased susceptibility to oxidative stress. PMID:23129554
7. Report increased GSTP1 in airways of asthmatic mice. PMID:23647087
8. DNIC storage function of GST P1-1 and ability of MRP1 to efflux DNICs are vital in protection against NO cytotoxicity PMID:22084240
9. Gst-pi expression of the prostate cancers are dependent on metastatic site. PMID:21748757
10. GSTP plays a major role in carcinogenesis distinct from its role in detoxification and provides evidence that the enzyme is a key determinant of the proinflammatory tumor environment. PMID:21975931
11. This study analysed the kinetic behaviour of all the various cysteine to alanine mutants of Gstp1. These mutations introduce cooperativity and a novel 'ping pong' mechanism in the case of the C169A mutant. PMID:21134126
12. Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines PMID:20538586
13. role in activating Pi-class glutathione S-transferase gene in conjunction with androgens PMID:12023900
14. Differential expression of GSTpi contributes to the sensitivity to xenobiotics in the substantia nigra and may influence the pathogenesis of reactive oxygen species-induced neurological disorders including Parkinson's disease. PMID:17267597
15. GSTP1 attenuates the severity of allergic airways disease. However, the efficacy of GSTP1 correlated with mouse strain-dependent variation in Gstp1 expression. PMID:18787219
16. Results suggest that GSTpi expression may be part of the mechanism underlying the ability of glial cells to elicit protection against the mechanisms involved in MPTP-induced neuronal death. PMID:18792812
17. GSTP1 prevented LPS-induced TNF-alpha, IL-1beta, MCP-1 and NO production. PMID:18962899
18. Catalysis of S-glutathionylation at low pK cysteines in proteins is a novel property for GSTpi PMID:18990698

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UNIGENE: Mm.299292

KEGG: mmu:14870

STRING: 10090.ENSMUSP00000129565