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Recombinant Mouse Gamma-interferon-inducible lysosomal thiol reductase (Ifi30)

Recombinant Mouse Gamma-interferon-inducible lysosomal thiol reductase (Ifi30)

Baculovirus

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Target Background

Product Details

Abbreviation

Ifi30

Purity

>85% (SDS-PAGE)

Target Names

Ifi30

Uniprot NO.

Q9ESY9

Alternative Names

Ifi30; Gilt; Ip30; Gamma-interferon-inducible lysosomal thiol reductase; EC 1.8.-.-; Gamma-interferon-inducible protein IP-30; Lysosomal thiol reductase IP30

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

55-230

Target Protein Sequence

PSPPVR VSLYYESLCG ACRYFLVRDL FPTWLMVMEI MNITLVPYGN AQERNVSGTW EFTCQHGELE CRLNMVEACL LDKLEKEAAF LTIVCMEEMD DMEKKLGPCL QVYAPEVSPE SIMECATGKR GTQLMHENAQ LTDALHPPHE YVPWVLVNEK PLKDPSELLS IVCQLYQGTE
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation.

Gene References into Functions

GILT has a role in maintaining cysteine cathepsin proteolytic efficiency in phagosomes PMID:25253686
These results show that wild-type mouse fibroblasts are relatively resistant and GILT(-/-)mouse fibroblasts are susceptible to Dengue virus 2 entry and replication. PMID:23642353
Data indicate that in the absence of Gamma-interferon-inducible lysosomal thiol reductase (GIL, CD4-positive T cell responses to major house dust mite allergen Der p 1 are significantly reduced. PMID:23326313
GILT has a critical role in regulating CD4(+) T-cell tolerance to an endogenous skin-restricted antigen relevant to controlling autoimmunity and generating effective immunotherapy for melanoma. PMID:21833020
gene knock-outs increase oxidative stress and autophagy, which is regulated by altering glutathione synthesis and oxidation PMID:21640818
GILT has limited yet unexpected effect on self-peptide species presented by major histocompatibility complex class II antigens. PMID:20485683
study shows GILT facilitates MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T cells or cross-presentation;initiation of gB-specific CD8+ T cell response during HSV-1 infection or cross-priming is GILT-dependent PMID:20538950
the thiol reductase activity of GILT is its essential function in MHC class II-restricted Ag processing PMID:17142755
findings show that endogenously produced peptide-IgG is processed by transduced splenic B cells in the lysosomes/endosomes in a GILT-dependent manner, and this endocytic processing pathway is essential for generating tolerogenic B cells PMID:18606668
Replication of Listeria monocytogenes in GILT-negative macrophages, or macrophages expressing an enzymatically inactive GILT mutant, is impaired because of delayed escape from the phagosome PMID:18815593
Expression of GILT in T-lymphocytes increases as a function of maturity, thereby reducing sensitivity of T-cells and consequences of autoimmune responses; a role of GILT in the immune system may be in reducing the impact of T-cell autoreactivity. PMID:19124716
GILT facilitated the processing and presentation to antigen-specific T cells of protein antigens containing disulfide bonds. PMID:11701933