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Recombinant Mouse Gamma-aminobutyric acid receptor-associated protein-like 1 (Gabarapl1)

Recombinant Mouse Gamma-aminobutyric acid receptor-associated protein-like 1 (Gabarapl1)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Gabarapl1

Purity

>85% (SDS-PAGE)

Target Names

Gabarapl1

Uniprot NO.

Q8R3R8

Alternative Names

Gabarapl1; Apg8l; Atg8l; Gec1; MNCb-0091Gamma-aminobutyric acid receptor-associated protein-like 1; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1; GEC-1

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-116

Target Protein Sequence

MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYG
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

Gene References into Functions

study of cerebral GABARAPL1 protein expression provides insight into its role in the development and homeostasis of the mouse brain PMID:23690988
analysis of specific functions of GABARAPL1 [review] PMID:21597319
Expression of mouse Atg8L in HEK293 cells led to cleavage of its C-terminus. (Atg8L/Apg8l)and is the fourth modifier of mammalian Atg8 conjugation. (ATG8L/Apg8L) PMID:16704426

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Subcellular Location

Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm, cytoskeleton. Endoplasmic reticulum. Golgi apparatus.

Protein Families

ATG8 family

Tissue Specificity

Expressed in testis and heart at high levels.

Database Links

UNIGENE: Mm.14638

KEGG: mmu:57436

STRING: 10090.ENSMUSP00000032264

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