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Recombinant Mouse G-protein coupled receptor family C group 6 member A (Gprc6a), partial

Recombinant Mouse G-protein coupled receptor family C group 6 member A (Gprc6a), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Gprc6a

Purity

>85% (SDS-PAGE)

Target Names

Gprc6a

Uniprot NO.

Q8K4Z6

Alternative Names

Gprc6aG-protein coupled receptor family C group 6 member A

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

Gene References into Functions

If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. PMID:28180060
findings imply the possibility to ameliorate menopause-induced metabolic disorder by GPRC6A and adiponectin signaling PMID:29194451
GPCR6A activation by Alum leads to the initiation of innate inflammatory responses whereas it is an important signal for the limitation of adaptive immune responses induced by Alum, partially explained by B cell IL-10. PMID:26602597
the loss of osteocalcin/Gprc6a signaling has a profound effect on beta-cell mass accrual during late pancreas morphogenesis PMID:24009262
the GPRC6A receptor is involved in regulating exercise behaviour PMID:23680430
Activation of GPRC6A by L-arginine did not stimulate insulin secretion. PMID:22714012
Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID:23271661
the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion PMID:23269670
GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. PMID:21681779
These findings suggest that GPRC6A is a candidate for mediating the response to Ocn in the bone-pancreas endocrine loop regulating insulin signaling. PMID:21425331
GPRC6A is functionally important in regulating non-genomic effects of androgens in multiple tissues. PMID:20947496
Osteoblasts and BMSCs derived from GPRC6A(-/-) mice exhibited an attenuated response to extracellular calcium-stimulated extracellular signal-related kinase (ERK) activation, diminished alkaline phosphatase expression, and impaired mineralization ex vivo PMID:19874200
Cloning and characterization of mouse GPRC6A family C orphan receptor show the highest degree of amino acid identity to the fish 5.24 odorant receptor and mammalian calcium-sensing receptor (CaSR). PMID:15816861
GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor PMID:16199532
GPRC6A(-/-) mice have a metabolic syndrome characterized by defective osteoblast-mediated bone mineralization, abnormal renal handling of calcium and phosphorus, fatty liver, glucose intolerance and disordered steroidogenesis. PMID:19050760
data do not support a role for GPRC6A in normal bone physiology PMID:19103720
GPRC6A is a promiscuous L-alpha-amino acid receptor most potently activated by basic amino acids. PMID:15576628

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Tissue Specificity

Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in E7, E11, E15 and E17 embryos.

Database Links

UNIGENE: Mm.221031

KEGG: mmu:210198

STRING: 10090.ENSMUSP00000020062

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