Recombinant Mouse Forkhead box protein O4 (Foxo4)

1. FOXO transcription factors play a salutary role in the protection against the diet-induced fatty liver disease. PMID:28300161
2. FoxOs exacerbate the loss of cancellous bone mass associated with type 1 diabetes. PMID:27491024
3. Foxo1, Foxo3a, and Foxo4 in chondrocytes regulate endochondral bone formation. PMID:26232637
4. The effect of Sirt1 stimulators on osteoclastogenesis was abrogated in cells lacking FoxO1, FoxO3, and FoxO4. PMID:26287518
5. FoxO4 is collectively required to maintain MODYrelated gene networks, which in turn are required to enable a gene expression program that permits proper substrate selection (glucose versus fatty acids) for mitochondrial oxidative phosphorylation. PMID:25264246
6. FoxO4 transcription factor is present during both oocyte and embryo in vivo maturation and FoxOs may regulate in vitro embryo development under stress conditions. PMID:25929834
7. FoxO4 activates Arg1 transcription in endothelial cells in response to MI, leading to downregulation of nitric oxide and upregulation of neutrophil infiltration to the infarct area. PMID:26438688
8. Foxo1, Foxo3, and Foxo4 transcriptional network regulates autophagy and the ubiquitin-proteasome system during muscle atrophy. PMID:25858807
9. Liver-specific ablation of FoxO1,FoxO3 and FoxO4 prevents the induction of glucose-6-phosphatase and the repression of glucokinase during fasting, thus increasing lipogenesis. PMID:25307742
10. FOXO1, FOXO3a and FOXO4, are indispensable for SIRT1-dependent cell survival against oxidative stress. PMID:24040102
11. FoxO1/3/4 transcription factors play important roles in hepatic glucose homeostasis. PMID:24015318
12. Mice lacking Foxo1, -3, and -4 in bipotential progenitors of osteoblast and adipocytes exhibit increased osteoblast number and high bone mass. PMID:23867625
13. Foxk1 promotes muscle progenitor cell proliferation by repressing Foxo4 transcriptional activity and inhibits myogenic differentiation by repressing Mef2 activity. PMID:22956541
14. Genetic ablation of the 3 genes encoding FoxO isoforms 1, 3a, and 4, in myeloid cells resulted in an expansion of the granulocyte/monocyte progenitor compartment and was associated with increased atherosclerotic lesion formation. PMID:23420833
15. FoxO4 inhibits atherosclerosis through bone marrow derived cells, possibly by inhibition of reactive oxygen species and inflammatory cytokines that promote monocyte recruitment and/or retention. PMID:22005198
16. In NIH3T3 cells, tetrahydrocurcumin induced nuclear accumulation of FOXO4 PMID:22156377
17. Data show that glomeruli isolated from diabetic db/db mice have increased acetylation of Foxo4, suppressed expression of Sirt1, and increased expression of Bcl2l11 compared to non-diabetic littermates. PMID:21858169
18. Foxo4 may be a useful target for suppression in the treatment of HBV-associated hepatocellular carcinoma cells. PMID:21567078
19. Data indicate that FoxOs work in concert to regulate multiple aspects of hepatic glucose metabolism. PMID:20880840
20. a conserved critical Ku70 role for FOXO function toward coordination of a survival program PMID:20570964
21. Using transcriptional assays, we observed that Fhl2, in a dose-dependent fashion, promotes Foxk1 transcriptional repression of Foxo4 activity. PMID:20013826
22. The forkhead transcription factor AFX activates apoptosis by induction of the BCL-6 transcriptional repressor. PMID:11777915
23. AFX (a Forkhead transcription factor = Foxo4) is expressed in the rodent ovary PMID:11875118
24. plays an important role in the regulation of GADD45 in response to oxidative stress and thereby contributes to G(2)-M checkpoint PMID:12048180
25. the MLL-AFX fusion protein requires the transcriptional effector domains of AFX to transform myeloid progenitors and interferes with forkhead protein function PMID:12192052
26. mechanism for oncogenic activation of MLL by forkhead family proteins designated FKHRL1 and AFX PMID:12393557
27. AGE-RAGE interaction contributes to podocyte apoptosis by activation of the FOXO4 transcription factor. PMID:17667983
28. FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity. PMID:17974917
29. Mdm2 induces mono-ubiquitination of FOXO4 PMID:18665269
30. The effect of tumor necrosis factor on atrogin-1 expression via Foxo protein metabolism is reported. PMID:18701653
31. A link between AMPK, glucose clearance, foxo4 and the leptin axis, is suggested. PMID:19410631
32. FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation. PMID:19560465
33. FOXO proteins enforce DNA damage-induced cell cycle arrest in hematopoietic cells. PMID:19671690

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UNIGENE: Mm.240299

KEGG: mmu:54601

STRING: 10090.ENSMUSP00000059420