Recombinant Mouse Fibulin-5 (Fbln5)

1. Fibulin-5 overexpression promoted the proliferation and migration of airway smooth muscle cell. PMID:28942149
2. Fibulin-5 overexpression significantly down-regulated the phosphorylation level of eIF2alpha and subsequently inhibited the TRPV1 channel and CREB/CGRP signaling PMID:28602628
3. Identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms. PMID:27089918
4. involved in the stiffening of fibrotic tissue PMID:26469761
5. Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease. PMID:26577699
6. While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative. PMID:26399686
7. Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review) PMID:25845228
8. These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly. PMID:24962333
9. Without LTBP-4, fibulin-5 and tropoelastin deposition was discontinuous and punctate in vitro and in vivo PMID:23382201
10. This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries. PMID:23241326
11. suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility PMID:22280367
12. MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans PMID:21519142
13. mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries PMID:20614245
14. These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production. PMID:20197418
15. Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury PMID:19893004
16. Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo. PMID:11805834
17. FBLN-5 is a novel TGF-beta-inducible target gene that regulates cell growth and motility in a context-specific manner and affects protein kinase activation by TGF-beta. PMID:12021267
18. coordinately expressed and regulated with elastin in lung fibroblasts and may serve a key role during lung injury and repair. PMID:12909585
19. The alterations in elastogenesis associated with increased fibulin-2 in hypodermal connective tissues and decreased fibulin-5 at the hypodermal M-CT interface suggest that these proteins mediate the effect of Tsk-fibrillin-1 on elastogenesis. PMID:15610515
20. role of fbln-5 as an inhibitor of vascular smooth muscle cell proliferation and migration. PMID:15710889
21. Fibulin-5 and elastic fibers are not directly involved in short-term wound healing. PMID:16902421
22. Fibulin-5 serves as an adaptor molecule between monomeric elastin and the matrix scaffold to aid in elastic fiber assembly. PMID:17130242
23. Mouse models of genetic macular degeneration include studies on Fbln5. PMID:17368622
24. These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers. PMID:17581631
25. the normal angiogenic process is enhanced in the absence of fibulin-5. PMID:17607303
26. a novel Epithelial-mesenchymal transition and tumor-promoting function for FBLN5 in developing and progressing breast cancers PMID:18713838
27. Fibulin 5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and increased vaginal protease activity (MMP-2 and MMP-9) precedes the development of prolapse. PMID:18987327
28. Fibulin-5 plays 2 roles in elastogenesis; 1st, limiting the extent of aggregation of tropoelastin monomers and/or coacervates and aiding the incorporation of elastin into the microfibril bundles, & 2nd, potentially assisting in the activation of LOXL-1. PMID:19321153

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UNIGENE: Mm.288381

KEGG: mmu:23876

STRING: 10090.ENSMUSP00000021603