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Recombinant Mouse Fibroblast growth factor 6 (Fgf6)

Recombinant Mouse Fibroblast growth factor 6 (Fgf6)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Fgf6

Uniprot NO.

P21658

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

38-208

Target Protein Sequence

SPA GARANGTLLD SRGWGTLLSR SRAGLAGEIS GVNWESGYLV GIKRQRRLYC NVGIGFHLQV PPDGRISGTH EENPYSLLEI STVERGVVSL FGVKSALFIA MNSKGRLYTT PSFHDECKFR ETLLPNNYNA YESDLYRGTY IALSKYGRVK RGSKVSPIMT VTHFLPRI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle regeneration.

Gene References into Functions

A crucial and unexpected role for FGF6 in muscle integrity and muscle protection against mechanical stress. PMID:21188410
In the absence of FGF6, the mechanisms leading to myofibre hypertrophy were mediated specifically by an IGF-II/IGF2R signalling pathway distinct from the classic mechanism involving IGF-I and IGF1R. PMID:15194422
a role for FGF6 in the maintenance of a reserve pool of progenitor cells in the skeletal muscle PMID:15389547
At high doses, FGF6 stimulates the proliferation of the myogenic stem cells, whereas at lower doses it regulates both muscle differentiation and muscle phenotype via a calcineurin-signaling pathway. PMID:15672378
might be involved in the changes of secretory granule content of acinar cells in the sublingual gland during the late gestational and early neonatal stages PMID:16617195
Involvement of FGF6 in myogenesis. Review. PMID:16875743
Rescue experiments supported the idea of a specific relationship between FGF6 and Spry 2, both being known for their particular involvement in myogenesis. PMID:18049951