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Recombinant Mouse Fanconi anemia group A protein homolog (Fanca), partial

Recombinant Mouse Fanconi anemia group A protein homolog (Fanca), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Fanca

Purity

>85% (SDS-PAGE)

Target Names

Fanca

Uniprot NO.

Q9JL70

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-1439

Target Protein Sequence

MPGSPARGAA MGGGPRGLRK TWTELLAGRV KKQKYDPERE QKLKDSALKL LRYHQNMHDL LLEVEEPQCK RLRLSELIDR DSADASSDRS ASFIRSAFRD QASRLGVPVG VLSAKVFARS VQQVCVEPSH PVLLSPEQSK KLSSLLMIAR HLLAQNMFSR LTFCQELWKA QNSLLLEAMW RLHTHSVVSL QELLQSHPDS EAMAMWLFRN LRSLCEQIGA SCPSPDTTEA MLSGLVQLLI SRGFQGSSDP RRLVEPERLP QVATDVLQRM LAFSLDTLEA DPQTTLDCQA VSGWIPIYSG HTCCGVVTEN SLKSFFSHTL TQILTHKPVL KVSDAIQMQK EWSFAKTHHL LTDLHCRVLA TLGPEESVGR LQEVLEMQEV NWQHVLSCVS TLVVCFPEAQ QLVKGWVASL MARAFESYHL DSMVTAFLIV RQATLEGPYV FPSYADWFKE SFGSSHGYHS CSKKTLVFLF KFLSDLVPWE APRYMQVHIF HPPLVPSKYH SLLTDYISLA KTRLADLKVS LENVGLYEDL SSPGDIAERE SQAVQDVKKA IMVFEQTGKI PMPVLEASIF RRPYYVSHFL PTLLAPRVLP EVPDPRVALI ETLKRADKIP SSIYDAYRKA CASAEKQQPE NATSAQRTEA DCAKEPLGLL TAALEELRAL MTDPTQYSVI SAQVAVVSEK LNAVLGHRND GGSLQRAKIQ LSVLPSTLQK QDQAVVDLLL TAFCQNLMAA SSFVPPERQS PWAVLFVRTL CGHVLLPAVL TRLRQLLRHQ GQSLSTSHVL GLAALAVHLG ECRSMLPEVD PDVLAPSAGS LCVPDFLNSL LTCRTRDSLL FCMNFCTAAV SYCLCKFSAL RNCLSPGLIK KFQFVVLRLF PEARAPCAPE HAACVPWRPL YLPSADWQRA ALSLWRRDSF QELLKDKEFY LTYRDWVQLE LEIQPEADVL SDMERHDFHQ WAIYERYLPA PTALGGCGGD LEEACTVLVS EIMDFHQSSR SYNHSEDSDL VLGGRTGNKD ILSRLQEIAL DLELDQGSAV PHGCSTPQSH FLFRVFRRRL QALARPDSMA TSLRRQQELL TCKRLLLCLP PSVLVGGPQA GQPISPNCGE FFSLVNSELR NFCCHGSVLT SDITIHFFRG LLRVCLRSQD PALVANQTLT ECQTKCPVIL TSALLWWSSL EPVLCGRWMR CYQSPLPREL RRLQEAREFA SNFASASASP APSPAWIAAA ALHFAWRGVR KEDVTAHLQR LDCQREELLI ALFFFSLMGL LSSYLTQRDT AEHLKAVDIC AEVLTCLERR KVSWLVLFQL TEKDAKLGHL LHLAPDQHTR LLPLAFYSLL SCFSEGAAVR EAAFLHVAVD MYLKLLQLFV DGETRLQGHS ESQGSPVQLI TKARVFLLQL IPQCPKQCFS NMTELLAGRG DCDPEVSNAL RQRQQADPSF DLYQEPQLF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be involved in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability.

Gene References into Functions

Fanca(-/-) mice showed a skewed Vkappa gene usage. PMID:27883081
FANCA safeguards interphase and mitosis during hematopoiesis PMID:26366677
study indicates that Fanca expression during endomitosis is crucial for normal megakaryopoiesis and platelet production. PMID:25261197
Data show that Fanconi anemia complementation group A Fanca is required for the induction of transition mutations at A/T residues during somatic hypermutation (SHM) and immunoglobulin (Ig) class switch recombination (CSR). PMID:24799500
CD25(+)Foxp3(+) Tregs of Fanca(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines. PMID:24501220
null mutations in Fanca or Fancg are fully epistatic PMID:22036606
genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population. PMID:21543111
The results support a model where both FANCA and FANCC are part of a multi-protein nuclear FA complex with identical function in cellular responses to DNA damage and germ cell survival. PMID:12135664
To study the in vivo role of the FA group A gene (Fanca), gene-targeting techniques were used to generate Fanca(tm1Hsc) mice in which Fanca exons 1-6 were replaced by a beta-galactosidase reporter construct. PMID:12913077
GnRH induced a rapid, transient increase in Fanca mRNA. PMID:15128600
Fanca protein as an integral component in the early step of homologous repair of DNA double-strand brearks thereby minimizing the genomic instability. PMID:15905196
Fanca knockout mice presented with microcephalies and a decreased neuronal production in developing cortex and adult brain, demonstrating a critical role for Fanconi pathway in neural stem and progenitor cells during developmental and adult neurogenesis. PMID:18239686