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Recombinant Mouse Ephrin type-A receptor 7 (Epha7), partial

Recombinant Mouse Ephrin type-A receptor 7 (Epha7), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Epha7

Purity

>85% (SDS-PAGE)

Target Names

Epha7

Uniprot NO.

Q61772

Alternative Names

Epha7; Ebk; Ehk3; Mdk1Ephrin type-A receptor 7; EC 2.7.10.1; Developmental kinase 1; mDK-1; EPH homology kinase 3; EHK-3; Embryonic brain kinase; EBK

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.

Gene References into Functions

The present study demonstrates that EphA7 receptors, despite their similar structure, have distinct in vivo effects on corticothalamic system projections into the ventrobasal complex /medial division of the posterior nuclear group. PMID:26587807
Results suggest that EphA7 plays an important role in the developmental formation of cochlear innervation pattern through controlling spiral ganglion neuron fiber ontogeny PMID:26178595
Truncated EPHA7 promotes cell reprogramming by inducing ERK activity reduction. PMID:26441306
Results support the hypothesis that the anatomical organization of striatal and thalamic neurons expressing EphA7 receptors restricts the topographic distribution of cortical afferents from medial regions of S1 which express high levels of ephrin-A5 PMID:24909897
The role of cell-based signaling via the receptor tyrosine kinase EphA7 in guiding the extension and maturation of cortical dendrites, was examined. PMID:24707048
multi-protein complex comprising ephrinA5, EphA7, and TNFR1 may constitute a platform for inducing caspase-dependent apoptotic PMID:23657875
This study demonstrated a potential role for EphA/ephrin-A signaling in the initial guidance of corticofugal axons. PMID:22490549
We used in utero electroporation-mediated EphA7 overexpression in developing somatosensory CT axons to dissect EphA7/ephrin-A-dependent mechanisms involved in regulating both initial targeting and postnatal growth of the corticothalamic projections. PMID:22821544
Our study identifies a novel repertoire of cortical neuron genes that may act upstream of, or together with EphA7, to control the patterning of cortical areas. PMID:21940705
Study identified EPHA7 as a tumor suppressor that is shed from germinal center B cells and lost in follicular lymphoma. PMID:22036564
The dorsal midline-specific EphA7 enhancer resides on the 457D20 EphA7 BAC clone and is localized to a 35 kb genomic region in between +345.7 kb to +379.8 kb downstream of the EphA7 transcription start site. PMID:21345310
Neocortical expression of Epha7 during development remains stable in the absence of cellular contacts and thalamocortical connections. PMID:12528186
ephrin-A/EphA receptor signalling plays a key role in controlling the size of the mouse cerebral cortex by regulating cortical progenitor cell apoptosis PMID:15902206
EphA7-mediated signaling on neocortical axons controls the within-nucleus topography of corticothalamic projections in the thalamus. (EphA7) PMID:16301174
EphA7 is a direct downstream target of Hoxd13 and Hoxa13 during limb development PMID:16314414