Recombinant Mouse Endothelial protein C receptor (Procr), partial

1. Leu8 is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice PMID:28035745
2. PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells. PMID:27670590
3. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. aPC-EPCR-PAR1 signaling promotes HSC retention in bone marrow. PMID:26457757
4. HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated. PMID:25892186
5. The protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression. PMID:25733582
6. Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo. PMID:24957146
7. knock-outs display diminished inflammatory immunity, enhanced blood coagulation as well as reduced bacterial growth in pneumococcal pneumonia and sepsis PMID:24401906
8. protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells PMID:25327250
9. FVIIa binding to EPCR leads to a barrier protective effect in vivo PMID:24977291
10. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding. PMID:24127121
11. FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides PMID:22950420
12. mineralocorticoid receptor activation has a role in enhancing endothelial protein C receptor and decreases vascular thrombosis in mice PMID:24451386
13. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID:23661674
14. Study demonstrates an important protective role for EPCR in vivo against vascular leakage during inflammation and suggests that EPCR-dependent vascular protection is organ-specific. PMID:23393392
15. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome. PMID:22903729
16. data indicate that it is possible to overexpress EPCR at a sufficient level to provide protection against transplant-related thrombotic and inflammatory injury PMID:22681753
17. Letter: Endothelial cell protein C receptor does not appear to play a significant role in human factor VIIa clearance from plasma. PMID:22372829
18. Murine FVIIa binds poorly to murine EPCR. PMID:22370814
19. EPCR interacts with the ternary TF coagulation initiation complex to enable PAR1,2 signaling. PMID:21149441
20. Blocking accelerates thrombus development PMID:20352165
21. EPCR(+) hematopoietic stem cells resided in the perisinusoidal niche in mouse fetal liver. PMID:20442369
22. EPCR was detected in the trophoblast. In the embryo, EPCR was weakly detected in aortic endothelial cells and thereafter, levels increased in certain large blood vessel endothelial cells. PMID:12195698
23. essential for normal embryonic development; plays a key role in preventing thrombosis at the maternal-embryonic interface PMID:12218060
24. minimal levels of EPCR are able to support male and female virility, as well as embryonic development, birth, and survival to adulthood. PMID:12353077
25. extraembryonic EPCR expression is critical for embryo development PMID:15956290
26. mEPCR, but not physiologically elevated sEPCR, regulated protein C activation. Procr heterozygosity results in a mild increase of thrombosis tendency and little influence on the response to endotoxin. PMID:17023579
27. activated protein C and its variants with reduced anticoagulant activity cross the blood-brain barrier via endothelial protein C receptor-mediated saturable transport PMID:18841163
28. expressed the extracellular region of the murine EPCR in a yeast expression system and obtained a colony of Pichia pastoris that produce high amounts of recombinant extracellular murine EPCR, which we purified by liquid chromatography to homogeneity PMID:19041722
29. APC molecular species with potent antithrombotic activity, but without robust cytoprotective activity, are not sufficient to reduce mortality in endotoxemia PMID:19244160
30. activated PC is barrier-protective in ventilator lung injury and EPCR is a critical participant in APC-mediated protection PMID:19363121
31. endogenous APC limits cancer cell extravasation because of S(1)P(1)-mediated VE-cadherin-dependent vascular barrier enhancement PMID:19571314

Show More

Hide All

UNIGENE: Mm.3243

KEGG: mmu:19124

STRING: 10090.ENSMUSP00000029140