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Recombinant Mouse Endothelial cell-selective adhesion molecule (Esam), partial

Recombinant Mouse Endothelial cell-selective adhesion molecule (Esam), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Esam

Purity

>85% (SDS-PAGE)

Target Names

Esam

Uniprot NO.

Q925F2

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Can mediate aggregation most likely through a homophilic molecular interaction.

Gene References into Functions

ESAM expression in hematopoietic progenitors is essential for erythroid recovery after a bone marrow injury. PMID:27111450
Runx3 is required for cell identity, homeostasis and function of splenic Esam(high) dendritic cells. PMID:24204843
ESAM levels clearly mirror the shift of hematopoietic stem cells (HSC) between quiescence and activation, and the intensity of expression is prominent in comparison with other HSC-related antigens. PMID:22649198
ESAM regulates tumor metastasis through endothelial cell migration and tube formation in metastatic nodules. PMID:20153339
ESAM inactivation can reduce susceptibility to atherosclerosis by inhibiting plaque neovascularization and macrophage infiltration into the atheroma. PMID:20406651
findings support a model in which ESAM localizes to platelet contacts following platelet activation in order to limit thrombus growth and stability PMID:19740102
selectively expressed on endothelial cells and platelets; might be involved in interendothelial cell adhesion PMID:11847224
ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth PMID:12819200
The direct interaction between ESAM and MAGI-1 was confirmed by pull-down experiments. The two proteins formed stable complexes in transfected CHO cells. PMID:15383320
At endothelial tight junctions ESAM participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. PMID:16818677
ESAM marks hematopoietic stem cells in murine fetal liver and will facilitate studies of hematopoiesis throughout life. PMID:19096010
Thus, ESAM may regulate albumin extravasation at the glomeruli and play a role in the initiation of diabetic nephropathy. PMID:19323980

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Subcellular Location

Cell junction, adherens junction. Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in the heart and lung. Weakly expressed in the kidney and skin. Expression is restricted to the vascular endothelial cells. Expressed in the kidney, heart and tongue (at protein level). Also expressed on megakaryocytes and activated plate

Database Links

UNIGENE: Mm.41751

KEGG: mmu:69524

STRING: 10090.ENSMUSP00000002011

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