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Recombinant Mouse ETS-related transcription factor Elf-3 (Elf3)

Recombinant Mouse ETS-related transcription factor Elf-3 (Elf3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Elf3

Purity

>85% (SDS-PAGE)

Target Names

Elf3

Uniprot NO.

Q3UPW2

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-391

Target Protein Sequence

MAATCEISNV FSNYFNAMYS SEDPTLAPAP PTTFGTEDLV LTLNNQQMTL EGPGPQTRSQ RDRTDPLAVL HLAEKASWTS ERPQFWSKTQ VLEWISYQVE KNKYDASSID FSRCDMDGAT LCSCALEELR LVFGPLGDQL HAQLRDLTSN SSDELSWIIE LLEKDGMSFQ ESLGDSGPFD QGSPFAQELL DDGRQASPYY CSTYGPGAPS PGSSDVSTAR TATPQSSHAS DSGGSDVDLD LTESKVFPRD GFPDYKKGEP KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG WKEEEVGESR N
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.

Gene References into Functions

ELF3 controls LCN2 expression in cooperation with NFkappaB. PMID:27222093
a novel role for ELF3 as a procatabolic factor that may contribute to cartilage remodeling and degradation by regulating MMP13 gene transcription. PMID:22158614
A novel function of Elf3 is identified that defines allergic airway inflammation caused by the regulation of dendritic cell-driven T helper (Th)1 cell, Th2 cell, and Th17 cell differentiation. PMID:21948981
Elf3 plays an important role in the regulation of lung cell proliferation and differentiation during repair of the injured bronchiolar airway epithelium. PMID:21709667
ESE-1 is an Ang II-inducible transcription factor that plays an important counter-regulatory role in the setting of vascular inflammation and remodeling. PMID:20689519
Elf3 amino acid residues within the flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 DNA binding and transactivation activity. PMID:20079749
Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor PMID:20054123
Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes. PMID:19801644
Evidence that mElf-3, a member of the Ets family, plays a key role in the activation of the mTbetaR-II promoter. PMID:11893733
ErbB2 activation of ESX gene expression PMID:12032832
Both proximal and distal regions that regulate Elf3 promoter activity were identified. PMID:15556300
Elf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport PMID:16516205

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

ETS family

Tissue Specificity

Expressed in small intestine, colon, lung, kidney and uterus. Also expressed in the corneal epithelium and conjunctiva of the developing and adult eye. Not detected in liver, spleen, thymus, brain, heart, skeletal muscle or ovary.

Database Links

UNIGENE: Mm.441439

KEGG: mmu:13710

STRING: 10090.ENSMUSP00000003135

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