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Recombinant Mouse ETS domain-containing transcription factor ERF (Erf)

Recombinant Mouse ETS domain-containing transcription factor ERF (Erf)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Erf

Uniprot NO.

P70459

Alternative Names

ErfETS domain-containing transcription factor ERF

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-551

Target Protein Sequence

MKTPADTGFA FPDWAYKPES SPGSRQIQLW HFILELLRKE EYQGVIAWQG DYGEFVIKDP DEVARLWGVR KCKPQMNYDK LSRALRYYYN KRILHKTKGK RFTYKFNFNK LVLVNYPFID MGLAGGAVPQ SAPPVPSGGS HFRFPPSTPS EVLSPTEDPR SPPACSSSSS SLFSAVVARR LGRGSVSDCS DGTSELEEPL GEDPRARPPG PPELGAFRGP PLARLPHDPG VFRVYPRPRG GPEPLSPFPV SPLAGPGSLL PPQLSPALPM TPTHLAYTPS PTLSPMYPSG GGGPSGSGGG SHFSFSPEDM KRYLQAHTQS VYNYHLSPRA FLHYPGLVVP QPQRPDKCPL PPMAPETPPV PSSASSSSSS SSSPFKFKLQ PPPLGRRQRA AGEKAPGGTD KSSGGSGSGG LAEGAGAVAP PPPPPQIKVE PISEGESEEV EVTDISDEDE EDGEVFKTPR APPAPPKPEP GEAPGVAQCM PLKLRFKRRW SEDCRLEGGG CLSGGPEDEG EDKKVRGDVG PGESGGPLTP RRVSSDLQHA TAQLSLEHRD S
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

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Target Background

Function(From Uniprot)

Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. May be important for regulating trophoblast stem cell differentiation.

Gene References into Functions

deletion of Erf rescues the proliferative defects of RAS-devoid embryonic stem cells and restores their capacity to differentiate. PMID:29650524
data provide evidence that the oncogenicity of ERG is mediated, in part, by competition with ERF and they raise the larger question of whether other gain-of-function oncogenic transcription factors might also inactivate endogenous tumour suppressors PMID:28614298
Results provide evidence that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs. PMID:28694332
Oncogenic Ras may play a role in epithelial mesenchymal transition via the ERF and regulation of Semaphorin-7a. PMID:22875994
These data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment. PMID:17502352
These studies suggest "repressing repressors" as a potential strategy for achieving utrophin up-regulation in Duchenne's muscular dystrophy, and they provide a model for utrophin-A regulation in muscle. PMID:17507653
Erf provides a direct link between the RAS/ERK signaling and the transcriptional regulation of c-Myc and suggests that RAS/ERK attenuation actively regulates cell fate PMID:17699159

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Subcellular Location

Nucleus.

Protein Families

ETS family

Tissue Specificity

Expressed along the osteogenic margins of the developing calvarial bones, in a similar distribution to that observed for the master osteogenic regulator RUNX2.

Database Links

UNIGENE: Mm.8068

KEGG: mmu:13875

STRING: 10090.ENSMUSP00000041912

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