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Recombinant Mouse ETS domain-containing protein Elk-3 (Elk3)

Recombinant Mouse ETS domain-containing protein Elk-3 (Elk3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Elk3

Uniprot NO.

P41971

Alternative Names

Elk3; Erp; NetETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-409

Target Protein Sequence

MESAITLWQF LLHLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPDI LKMDPHAVEI SRESLLLQDG DCKVSPEGRE VHRHGLSSLK SASRNEYLHS GLYSSFTINS LQNAPEAFKA IKTEKLEEPC DDSPPVEEVR TVIRFVTNKT DKHITRPVVS LPSTSETAAA AASAFLASSV SAKISSLMLP NAASISSASP SSSRSPSLSP DSPLPSEHRS LFLEAACHDS DSLEPLNLSS GSKTKSPSLP PKGKKPKGLE ISAPQLLLSG TDIGSIALNS PALPSGSLTP AFFTAQTPSG LFLASSPLLP SIHFWSSLSP VAPLSPARLQ GPNTLFQFPT LLNGHMPVPL PSLDRAPSPV LLSPSSQKS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene References into Functions

Dexmedetomidine attenuates pancreatic injury and inflammatory response in mice with pancreatitis possibly by reducing NLRP3 activation and up-regulating NET expression. PMID:29269298
Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling. PMID:27538444
Elk3 has distinct roles in maintaining retinal artery integrity. PMID:25203538
coexpression of KLF4 led to repression of Elk-3 promoter activity PMID:25351511
ELK3 suppresses PAI-1 expression and accumulates in the nucleus at high cell density. PMID:23708702
Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2 PMID:12896968
A regulator of angiogenesis that can switch to an activator following induction by pro-angiogenic molecules. PMID:12975317
Net is a negative regulator of PAI-1 expression and is thereby involved in cell migration. PMID:16314510
Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1) gene transcription and contributes to the tight control of HO-1 gene regulation in the setting of inflammatory stimuli PMID:16456000
Data show that hypoxia regulates Net differently from the other ternary complex factors and that Net plays a role in the hypoxic response in vivo in mice and in cells. PMID:17403894
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID:18316589