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Recombinant Mouse ERBB receptor feedback inhibitor 1 (Errfi1)

Recombinant Mouse ERBB receptor feedback inhibitor 1 (Errfi1)

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Conjugate
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Target Background

Product Details

Abbreviation

Errfi1

Purity

>85% (SDS-PAGE)

Target Names

Errfi1

Uniprot NO.

Q99JZ7

Alternative Names

Errfi1; Mig6ERBB receptor feedback inhibitor 1; Mitogen-inducible gene 6 protein homolog; MIG-6

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-461

Target Protein Sequence

STAGVAAQD IRVPLKTGFL HNGQALGNMK SCWGSHSEFE NNFLNIDPIT MAYNLNSPAQ EHLTTVGCAA RSAPGSGHFF AECGPSPRSS LPPLVISPSE SSGQREEDQV MCGFKKLSVN GVCTSTPPLT PIKSCPSPFP CAALCDRGSR PLPPLPISED LCVDEADSEV ELLTTSSDTD LLLEDSAPSD FKYDAPGRRS FRGCGQINYA YFDSPTVSVA DLSCASDQNR VVPDPNPPPP QSHRRLRRSH SGPAGSFNKP AIRISSCTHR ASPSSDEDKP EVPPRVPIPP RPAKPDYRRW SAEVTSNTYS DEDRPPKVPP REPLSRSNSR TPSPKSLPSY LNGVMPPTQS FAPDPKYVSS KALQRQSSEG SANKVPCILP IIENGKKVSS THYYLLPERP PYLDKYEKYF KEAEETNPST QIQPLPAACG MASATEKLAS RMKIDMGSHG KRKHLSYVVS P
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

Gene References into Functions

Study showed that Mig-6 has an important function of tumor suppressor via inhibition of STAT3 phosphorylation in uterine epithelial cells, and the antitumor effects of progesterone are mediated by the endometrial stroma. PMID:28925396
Mig-6 deficiency promotes the development of Kras(G12D)-induced lung adenoma through reducing the cell apoptosis in Kras(G12D) mouse lungs partially by activating the ErbB4 pathway. PMID:29191600
Studies indicate that progesterone receptor transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 and its target genes. PMID:27910070
mouse Mig-6 ablation in the liver results in multiple metabolic phenotypes such as fatty liver, fasting hyperglycemia, and hypercholesterolemia but in lower bodyweight and improved insulin sensitivity. PMID:28053990
Liver-specific ablation of Mig-6 caused hyperglycemia by hepatic insulin resistance. PMID:25594850
MIG6 is a potent tumor suppressor for mutant EGFR-driven lung tumor initiation and progression in mice and provides a possible mechanism by which mutant EGFR can partially circumvent this tumor suppressor in human lung adenocarcinoma. PMID:25735773
This microarray analysis also revealed that 324 genes are regulated by P4 as well as Mig-6. Cited2, the developmentally important transcription factor, was identified as being regulated by the P4-Mig-6 axis PMID:25976672
Mig-6 plays a critical role in the development of atherosclerosis. PMID:25574067
our findings suggest that Mig-6 regulates ERK1/2 phosphorylation and that it is crucial for progression of PTEN-mutant endometrial cancers, providing a mechanistic rationale for the evaluation of ERK1/2 inhibitors PMID:25377472
MIG-6 expression in chondrocytes is important for the maintenance of cartilage and joint homeostasis. PMID:24966136
Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation. PMID:24550287
This treatment had no effect in PR(cre/+)Mig-6(f/f) mice where Mig-6 was deleted in both the epithelial and stromal compartments of the uterus. PMID:23811943
The sustained production of Mig6 protein exacerbates endoplasmic reticulum stress-induced beta-cell death. PMID:23204325
Mig-6 plays a critical role in the regulation of cholesterol homeostasis and bile acid synthesis. PMID:22912762
Mig6 functions as a molecular brake for beta-cell proliferation during glucocorticoid treatment in beta-cells, and thus, Mig6 may be a novel target for preventing glucocorticoid-induced impairments in functional beta-cell mass. PMID:23384834
The Mig6 activates c-Abl by binding to the kinase domain, which is prevented in the presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr488. PMID:22975324
multifaceted genomic evaluation of glioblastoma establishes ERRFI1 as a potential candidate tumor suppressor gene and TACC3 as a potential oncogene, and provides insight on targets for oncogenic pathway-based therapy PMID:21113414
results suggest that Mig-6 exerts a tumor-suppressor function in endometrial cancer by promoting epithelial cell apoptosis through the downregulation of the estrogen-induced apoptosis inhibitors Birc1 and the inhibition of ERK2 phosphorylation PMID:20418913
Using Errfi1(d/d) mice, Errfi1 was identified as an important mediator of uterine implantation. Epithelial ESR1 and target genes were significantly increased in the uteri of Errfi1(d/d) mice. PMID:20018910
Mig-6 controls EGFR trafficking and suppresses gliomagenesis PMID:20351267
Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. PMID:20044804
RALT behaves as a suppressor of EGFR signalling in mouse skin PMID:16007071
loss of Mig-6 leads to early onset of joint disease PMID:16087873
The Mitogen-inducible gene 6 negatively regulates HGF/Met-induced cell migration. PMID:16247031
Results indicate that Mig6 is a specific negative regulator of Egfr signaling in skin morphogenesis and is a novel tumor suppressor of Egfr-dependent carcinogenesis. PMID:16648858
Cardiac overexpression of RALT improves cardiac function and inhibits maladaptive hypertrophy, inflammation, and fibrosis through attenuating epidermal growth factor receptor-dependent signaling. PMID:19204184
Mig-6 is a critical regulator of the response of the endometrium to estrogen in regulating tissue homeostasis PMID:19439667
Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization. PMID:19710174

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Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Note=Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.

Protein Families

MIG6 family

Tissue Specificity

Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium.

Database Links

UNIGENE: Mm.318841

KEGG: mmu:74155

STRING: 10090.ENSMUSP00000030811

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