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Recombinant Mouse E3 ubiquitin-protein ligase UBR5 (Ubr5), partial

Recombinant Mouse E3 ubiquitin-protein ligase UBR5 (Ubr5), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Ubr5

Purity

>85% (SDS-PAGE)

Target Names

Ubr5

Uniprot NO.

Q80TP3

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

2-2792

Target Protein Sequence

TSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR TSRPGRTSDS PWFLSGSETL GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI PASVIPEELI SQAQVVLQGK SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE SYLPGEDLMS LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRERDSE LLRERESVLR LRERRWLDGA SFDNERGSTS KEGESNPDKK NTPVQSPVSL GEDLQWWPDK DGTKFTCIGA LYSELLAVSS KGELYQWKWS ESEPYRNAQN PSLHHPRATF LGLTNEKIVL LSANSIRATV ATENNKVATW VDETLSSVAS KLEHTAQTYS ELQGERIVSL HCCALYTCAQ LENNLYWWGV VPFSQRKKML EKARAKNKKP KSSAGISSMP NITVGTQVCL RNNPLYHAGA VAFSISAGIP KVGVLMESVW NMNDSCRFQL RSPESLKSME KASKTLETKP ESKQEPVKTE MGPPPSPAST CSDASSIASS ASMPYKRRRS TPAPREEEKV NEEQWPLREV VFVEDVKNVP VGKVLKVDGA YVAVKFPGTS TNTTCQNSSG PDADPSSLLQ DCRLLRIDEL QVVKTGGTPK VPDCFQRTPK KLCIPEKTEI LAVNVDSKGV HAVLKTGSWV RYCVFDLATG KAEQENNFPT SSVAFLGQDE RSVAIFTAGQ ESPIVLRDGN GTIYPMAKDC MGGIRDPDWL DLPPISSLGM GVHSLINLPA NSTIKKKAAI IIMAVEKQTL MQHILRCDYE ACRQYLVNLE QAVVLEQNRQ MLQTFISHRC DGNRNILHAC VSVCFPTSNK ETKEEEEAER SERNTFAERL SAVEAIANAI SVVSSNGPGN RAGSSNSRSL RLREMMRRSL RAAGLGRHEA GASSSDHQDP VSPPIAPPSW VPDPPSMDPD GDIDFILAPA VGSLTTAATG SGQGPSTSTI PGPSTEPSVV ESKDRKANAH FILKLLCDSA VLQPYLRELL SAKDARGMTP FMSAVSGRAY SAAITILETA QKIAKAEVSA SEKEEDVFMG MVCPSGTNPD DSPLYVLCCN DTCSFTWTGA EHINQDIFEC RTCGLLESLC CCTECARVCH KGHDCKLKRT SPTAYCDCWE KCKCKTLIAG QKSARLDLLY RLLTATNLVT LPNSRGEHLL LFLVQTVARQ TVEHCQYRPP RIREDRNRKT ASPEDSDMPD HDLEPPRFAQ LALERVLQDW NALRSMIMFG SQENKDPLSA SSRIGHLLPE EQVYLNQQSG TIRLDCFTHC LIVKCTADIL LLDTLLGTLV KELQNKYTPG RREEAIAVTM RFLRSVARVF VILSVEMASS KKKNNFIPQP IGKCKRVFQA LLPYAVEELC NVAESLIVPV RMGIARPTAP FTLASTSIDA MQGSEELFSV EPLPPRPSSD QASSSSQSQS SYIIRNPQQR RISQSQPVRG RDEEQDDIVS ADVEEVEVVE GVAGEEDHHD EQEEHGEENA EAEGHHDEHD EDGSDMELDL LAAAETESDS ESNHSNQDNA SGRRSVVTAA TAGSEAGASS VPAFFSEDDS QSNDSSDSDS SSSQSDDIEQ ETFMLDEPLE RTTNSSHANG AAQAPRSMQW AVRNPQHQRA ASTAPSSTST PAASSAGLIY IDPSNLRRSG TISTSAAAAA AALEASNASS YLTSASSLAR AYSIVIRQIS DLMGLIPKYN HLVYSQIPAA VKLTYQDAVN LQNYVEEKLI PTWNWMVSVM DSTEAQLRYG SALASAGDPG HPNHPLHASQ NSARRERMTA REEASLRTLE GRRRATLLSA RQGMMSARGD FLNYALSLMR SHNDEHSDVL PVLDVCSLKH VAYVFQALIY WIKAMNQQTT LDTPQLERKR TRELLELGID NEDSEHENDD DTSQSATLND KDDDSLPAET GQNHPFFRRS DSMTFLGCIP PNPFEVPLAE AIPLADQPHL LQPNARKEDL FGRPSQGLYS SSAGSGKCIV EVTMDRNCLE VLPTKMSYAA NLKNVMNMQN RQKKEGEEQS LLAEEADSSK PGPSAPDVAA QLKSSLLAEI GLTESEGPPL TSFRPQCSFM GMVISHDMLL GRWRLSLELF GRVFMEDVGA EPGSILTELG GFEVKESKFR REMEKLRNQQ SRDLSLEVDR DRDLLIQQTM RQLNNHFGRR CATTPMAVHR VKVTFKDEPG EGSGVARSFY TAIAQAFLSN EKLPNLDCIQ NANKGTHTSL MQRLRNRGER DREREREREM RRSSGLRAGS RRDRDRDFRR QLSIDTRPFR PASEGNPSDD PDPLPAHRQA LGERLYPRVQ AMQPAFASKI TGMLLELSPA QLLLLLASED SLRARVDEAM ELIIAHGREN GADSILDLGL LDSSEKVQEN RKRHGSSRSV VDMDLEDTDD GDDNAPLFYQ PGKRGFYTPR PGKNTEARLN CFRNIGRILG LCLLQNELCP ITLNRHVIKV LLGRKVNWHD FAFFDPVMYE SLRQLILASQ SSDADAVFSA MDLAFAIDLC KEEGGGQVEL IPNGVNIPVT PQNVYEYVRK YAEHRMLVVA EQPLHAMRKG LLDVLPKNSL EDLTAEDFRL LVNGCGEVNV QMLISFTSFN DESGENAEKL LQFKRWFWSI VEKMSMTERQ DLVYFWTSSP SLPASEEGFQ PMPSITIRPP DDQHLPTANT CISRLYVPLY SSKQILKQKL LLAIKTKNFG FV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Plays an essential role in extraembryonic development. Regulates DNA topoisomerase II binding protein (TopBP1) for the DNA damage response.

Gene References into Functions

Hence, while loss of UBR5 perturbed Hedgehog signalling in the developing limb, there were no obvious morphological defects. PMID:27299863
Findings unveil UBR5 as a novel and critical regulator of tumor growth, metastasis, and immune response in triple negative breast cancer. PMID:28330927
UBR5-mediated ATMIN ubiquitination is a vital event for ATM pathway selection and activation in response to DNA damage PMID:25092319
a novel function of RIP1 kinase involving its interaction with EDD to regulate JNK activation and TNFalpha production. PMID:22695613
Silencing Edd1 with shRNA in mouse embryonic stem cells significantly suppressed their growth. PMID:23326633
The SCF E3 ligase complex containing Fbxo40 directly ubiquitinates IRS1, and this activity is enhanced by increased tyrosine phosphorylation of IRS1. PMID:22033112
Through the PABC domain, EDD participates in miRNA silencing by recruiting downstream effectors. PMID:21726813
UBR5 can attenuate myocardin protein degradation resulting in increased myocardin protein expression without affecting myocardin mRNA expression. PMID:20167605
Results suggest that Edd has an essential role in extraembryonic development. PMID:15282321