Recombinant Mouse Dystroglycan (Dag1), partial

1. alpha-DG hypoglycosylation, together with an increased protein instability, reduces the membrane dynamics of the beta-subunit and its clustering within the actin-rich domains, influencing cell migration and spontaneous cell movement. PMID:28572004
2. Utrn KO mdx mice but not mdx mice show decreased expression of serum N-terminal alpha Dystroglycan compared to normal mice. PMID:27854211
3. Loss of dystroglycan glycosylation is associated with dystroglycanopathies leading to a breakdown of muscle cell membrane integrity and eventual degeneration. PMID:29320543
4. These results reveal a role for DG in maintaining the stability of the sarcomeric cytoskeleton during contraction. PMID:27625424
5. Integrin beta1 and dystroglycan compensate each other to mediate laminin-dependent basement membrane assembly and epiblast polarization. PMID:27449702
6. Cleavage of beta-DG still occurred when both MMP-2 and MMP-9 were knocked out in gamma - sarcoglycan-deficient mice. The study found that up-regulation of MMP-14 is capable of cleaving beta-DG, and it may be involved in the pathogenesis of sarcoglycanopathy. PMID:28821434
7. The extracellular environment plays a critical role in coordinating neuronal migration and neurite outgrowth during neural circuit development. PMID:28760865
8. we provide evidence that a subset of GABAergic interneurons requires dystroglycan for formation and maintenance of axonal terminals on pyramidal cells PMID:27707967
9. These findings reveal a role for dystroglycan in orchestrating both the assembly and function of the subventricular zone neural stem cell niche PMID:27569418
10. Fktn deficient mice express moderate to severe muscular dystrophy; glycosylated alpha-dystroglycan has a unique role in muscle regeneration in these mice PMID:26751696
11. A glucuronic acid beta1,4-xylose disaccharide synthesized by B4GAT1 acts as an acceptor primer that can be elongated by LARGE with the ligand-binding heteropolysaccharide. PMID:25279699
12. This study demonstrated that the Postnatal development of the molecular complex underlying astrocyte polarization. PMID:24777283
13. The X-ray crystal structure of the missense variant T190M of the murine N-terminal domain of alpha-dystroglycan (50-313) has been determined. PMID:25932631
14. 5-amino-4-imidazolecarboxamide riboside treatment increases utrophin A and beta-dystroglycan expression in mdx mouse muscle. PMID:25324540
15. Phosphorylation within the cysteine-rich region of dystrophin enhances its association with beta-dystroglycan and identifies a potential novel therapeutic target for skeletal muscle wasting. PMID:25082828
16. Results suggest that by interfering in the cross-talk between the transmembrane form of the laminin receptor dystroglycan and F-actin, AHNAK1 influences the cytoskeleton organization of Schwann cells PMID:24796807
17. We evaluate the key characteristics of the mdx in comparison with other mouse mutants with inactivations in DAPC components, along with key modifiers of the disease phenotype. PMID:25270874
18. results indicate a novel role for laminin-dystroglycan interactions in the cooperative integration of astrocytes, endothelial cells, and pericytes in regulating the Blood Brain Barrier. PMID:25392494
19. Endogenous glucuronyltransferase activity of LARGE or LARGE2 required for functional modification of alpha-dystroglycan in cells and tissues. PMID:25138275
20. Beta-dystroglycan can respond to ezrin driven cytoskeletal and cell morphology changes,by translocating from the cytoplasm to the nucleus. PMID:24599031
21. Down-regulation of beta-dystroglycan leads to dysfunctions of astrocytic endfeet in the epileptic cerebral cortex. PMID:25228692
22. Alpha dystroglycan is a perlecan receptor that specifically functions in the stellate reticulum of the embryonic stage. PMID:23722005
23. The study provides evidence for at least three separate pools of dystroglycan complexes within myofibers that differ in composition and are differentially affected by loss of dystrophin. PMID:23951345
24. model confirms dystroglycan phosphorylation as an important pathway in the aetiology of Duchenne muscular dystrophy PMID:22810924
25. This study demonistrated that the axonal guidance defects observed in dystroglycan mutant mice. PMID:23217742
26. This study verified that Dag1 mRNA is expressed by RG cells in the embryonic subventricular zone , whereas DG protein is localized to glia end feet in contact with the pial basement membrane. PMID:23147502
27. Our data provides novel evidence that functionally links the teneurin and dystroglycan systems and provides new insight into the molecular mechanisms by which TCAP-1 regulates cytoskeletal dynamics in hippocampal neurons PMID:22698694
28. Cajal band appositions contain a dystroglycan complex that includes periaxin and dystrophin-related protein (Drp)2. PMID:22764250
29. one form of glycosylation can influence another form of glycosylation in alpha-DG and suggest that in the absence of proper O-mannosylation, as is associated with certain forms of muscular dystrophy PMID:22549772
30. Data show that in Dp71-null mice, the levels of beta-dystroglycan (beta-DG) and alpha1-syntrophin (alpha1-Syn) were lower and utrophin expression did not change, and the neuronal nitric oxide synthase (nNOS) expression and activity were increased. PMID:22493004
31. alpha-DG prepared from lung- or testis-derived cells lacks the post-phosphoryl moiety and shows little laminin a1 and a2 binding activity. PMID:22270369
32. Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase. PMID:21930648
33. Age-related alterations in beta-dystroglycan are observed in the intrinsic laryngeal muscles of mdx mice. PMID:22102469
34. Cleavage of dystroglycan by matrix metalloproteinases 2 and 9 is regulated in normal nerves and modulates dystroglycan complex composition and the size of Schwann cell compartments. PMID:21865464
35. Dystroglycan is a functional laminin 211 receptor during axonal sorting and the key substrate relevant to the pathogenesis of glycosyltransferase congenital muscular dystrophies. PMID:21862561
36. DG is necessary for the formation of the glial endfoot architecture. PMID:21501259
37. results indicate that overexpression of LARGE catalyzes the glycosylation of at least one other glycoprotein in addition to alpha-DG, and that this glycosylation(s) promotes laminin binding activity PMID:21533062
38. classical beta1,2-elongation and beta1,6-GlcNAc branching of O-mannose glycan structures are dependent upon the POMGnT1 enzyme and O-mannosylation is not limited solely to alpha-DG in the brain PMID:21460210
39. LARGE has a role in inducing alpha-dystroglycan hyperglycosylation in skeletal and cardiac muscle PMID:21203384
40. required for the growth and function of a mammalian epithelial tissue; controls STAT5-dependent hormone signaling pathways PMID:20940259
41. These results indicate that pikachurin interactions with alpha-dystroglycan and its localization at the photoreceptor ribbon synapse require normal glycosylation of alpha-dystroglycan. PMID:21129441
42. Results indicate that appropriate glycosylation of alpha-dystroglycan has an important role in the maintenance of podocyte architecture. PMID:20944549
43. Dystroglycan does not contribute significantly to kidney development or function, in health or after injury. PMID:21209007
44. DG function is modulated by glycosylation during T cell development in vivo, and DG is essential for normal development and differentiation of T cells PMID:20369005
45. alpha-dystroglycan is necessary for neuregulin-, agrin-, and laminin-induced Egr3 expression during muscle spindle formation. PMID:20213761
46. Our findings provide genetic evidence that neuronal dystroglycan plays a role in synaptic plasticity and that glial dystroglycan is involved in forebrain development PMID:20980614
47. Post-translational maturation of dystroglycan is necessary for pikachurin binding and ribbon synaptic localization. PMID:20682766
48. cerebral hypoxia promotes first an endothelial response followed by astrocyte activation, proliferation, and reorganization of astrocyte end-feet, which correlates with increased expression of adhesion molecules alpha 6 beta 4 integrin and dystroglycan PMID:20544851
49. severe sepsis leads to a marked reduction in membrane localization of dystrophin and beta-dystroglycan in septic cardiomyocytes PMID:20142806
50. dystroglycan in luminal epithelial cells is not required for the maintenance of basement membranes, cell polarity or prostate regeneration. PMID:20054819

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[Alpha-dystroglycan]: Secreted, extracellular space.; [Beta-dystroglycan]: Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Note=The monomeric form translocates to the nucleus via the action of importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3. Localizes to neuromuscular junctions (NMJs). In adult muscle, NMJ localization depends upon ANK2 presence, but not in newborn animals. In peripheral nerves, localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli.

Detected in brain and kidney (at protein level). Detected in sciatic nerve (at protein level). Expressed in neurons and muscle cells (at protein level). Expressed in a variety of tissues. In brain, expressed in the hippocampal formation, the olfactory bul

UNIGENE: Mm.491797

KEGG: mmu:13138

STRING: 10090.ENSMUSP00000079294