Recombinant Mouse Dual specificity mitogen-activated protein kinase kinase 2 (Map2k2)

1. MK2/3 cascade plays a strategic role in controlling synaptic plasticity and cognition. PMID:25134715
2. MK2 attenuates dendritic cell-mediated Th1 differentiation and autoimmune encephalomyelitis. PMID:26078274
3. analysis of p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells PMID:25332232
4. MK2 is responsible for resistance of p53-deficient tumors to cisplatin PMID:24239348
5. MK2 plays a critical role in the development of apoptosis. PMID:24304496
6. A critical role is indicated for p38 effector kinase MK2 in the regulation of tumor necrosis factor (TNF)-alpha messenger RNA (mRNA) translation through the TRIF signaling pathway. PMID:20375303
7. Pin1 regulates BPGAP1 function in Rho and Erk signalling, with active Mek2 serving as a novel regulatory scaffold that promotes crosstalk between RhoGAP, Pin1 and Erk in the regulation of cell migration. PMID:20179103
8. Results suggest a role for MK2 in the regulation of muscle mass, a role which, at least in part, may be related to determining the subcellular localization of p38 in muscle fibers. PMID:20049871
9. MK2, in contrast to its downstream effector molecule, TNF-alpha, has a rather elusive role in T-cell-dependent cutaneous inflammation PMID:19657354
10. MK2 signaling has a minor role in skin inflammation [commentary] PMID:20081887
11. MK2 stabilizes p38 MAPK through its C terminus and that MK2 catalytic activity does not contribute to this stabilization. PMID:12052889
12. MK2 has a role in cytokine expression and in cell migration [review] PMID:12440954
13. our findings demonstrate that MEK2 is not necessary for the normal development of the embryo and T-cell lineages, suggesting that the loss of MEK2 can be compensated for by MEK1. PMID:12832465
14. MK2 inhibits the mRNA destabilizing activity of tristetraprolin and, in parallel, codegradation of tristetraprolin together, with the target mRNA resulting in increased cellular levels of tristetraprolin. PMID:16508014
15. MK2-dependent insolubilization of Hsp25 oligomers has a role in susceptibility to cell stress PMID:16840785
16. Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 are two independent signaling pathways that cooperate to control T cell receptor-mediated ICOS induction PMID:16880206
17. These results indicate a critical role of p38-MK2-dependent induction of MKP-1 in innate PMID:16978838
18. MK2 mediates the incorporation of p38 into the pre-existing complex of hsp27 with Akt PMID:17015449
19. MK2-HSP27 pathway is a target for therapeutic control of localized inflammatory diseases. PMID:17576778
20. MK2 critically promotes atherogenesis by fostering foam cell formation and recruitment of monocytes/macrophages into the vessel wall. PMID:17885219
21. p38 MAP kinase and its downstream effector MK2 mediate lung permeability in ventilator associated lung injury by regulating HSP25 phosphorylation and actin cytoskeletal remodeling. PMID:19240800
22. MK2 deficient mouse macrophages produce markedly decreased levels TNF-alpha than wild type macrophages. PMID:19359247
23. MK2 has a role in the early stages of tumor promotion through regulation of both the inflammatory response and apoptosis of DNA-damaged cells PMID:19808857

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UNIGENE: Mm.275436

KEGG: mmu:26396

STRING: 10090.ENSMUSP00000121111