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Recombinant Mouse Diablo homolog, mitochondrial (Diablo)

Recombinant Mouse Diablo homolog, mitochondrial (Diablo)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Diablo

Purity

>85% (SDS-PAGE)

Target Names

Diablo

Uniprot NO.

Q9JIQ3

Alternative Names

Diablo; SmacDiablo homolog; mitochondrial; Direct IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

54-237

Target Protein Sequence

AVPIAQK SEPQSLSNEA LMRRAVSLVT DSTSTFLSQT TYALIEAITE YTKAVYTLVS LYRQYTSLLG KMNSQEEDEV WQVIIGARVE MTSKQQEYLK LETTWMTAVG LSEMAAEAAY QTGADQASIT ARNHIQLVKS QVQEVRQLSQ KAETKLAEAQ TKELHQKAQE VSDEGADQEE EAYLRED
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases.

Gene References into Functions

We report that an Smac-mimetic selectively induces TNF-alpha-dependent cystic renal epithelial cell death, leading to the removal of cystic epithelial cells from renal tissues and delaying cyst formation. PMID:23990677
Results demonstrate an essential and apoptosis-independent function of SMAC in tumor suppression and provide new insights into the biology and targeting of colon cancer. PMID:22751125
Loss of Smac/DIABLO alters both caspase-dependent and caspase-independent intrinsic programmed cell death. PMID:21597464
Membrane-associated XIAP induces mitochondrial outer membrane permeabilization leading to cytochrome c and Smac release, which is dependent on Bax and Bak. PMID:19875445
data suggest the existence of a redundant molecule or molecules capable of compensating for a loss of Smac/DIABLO function. PMID:11971981
mitochondrial activation by Bid is required for reversing the inhibitor-of-apoptosis proteins inhibition through Smac release PMID:12011074
Diablo was present within the mitochondria of healthy cells, but released into the cytosol following the induction of apoptosis by UV. PMID:12058276
Transient focal ischemia was produced for 1 hour in mice. Mitochondrial levels of DIABLO increased after 2-11 h reperfusion. DIABLO increased in the cytosol after 5 h reperfusion, implying the translocation of DIABLO into the cytosol. PMID:12395105
Bax and Bak differentially regulate the release of cytochrome c and Smac/DIABLO from mitochondria, and Smac/DIABLO can be used to sensitize cells that are deficient in Bax and Bak genes, or resistant to TRAIL. PMID:12670926
Regulation of Smac/Diablo mRNA and protein expression is a mechanism by which lethal stimuli amplify their lethal potential in renal cells. PMID:12969128
These results suggest that interaction among XIAP, Smac/DIABLO, and caspase-9 plays an important role in the regulation of apoptotic neuronal cell death after transient focal cerebral ischemia. PMID:12973017
Smac/DIABLO is involved in the fragmentation and apoptosis of preimplantation embryos. PMID:15709158
release of Smac/DIABLO from mitochondria to cytoplasm and the subsequent activation of caspase-9 and caspase-3 play important roles in H(2)O(2)-induced apoptosis in C2C12 myogenic cells PMID:16085184
Smac/DIABLO and Hsp-70 proteins were upregulated 2-fold and 1.5-3-fold, respectively, after birth. PMID:17914183