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Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial

Recombinant Mouse Cytokine receptor-like factor 2 (Crlf2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Crlf2

Purity

>85% (SDS-PAGE)

Target Names

Crlf2

Uniprot NO.

Q8CII9

Alternative Names

Crlf2; Crlm2; Tpte2; TslprCytokine receptor-like factor 2; Cytokine receptor-like molecule 2; CRLM-2; Thymic stromal lymphopoietin protein receptor; TSLP receptor; Type I cytokine receptor delta 1

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system.

Gene References into Functions

A novel mouse xenograft model to study the role of TSLP-induced CRLF2 signals in normal and malignant human B lymphopoiesis has been developed. PMID:26611474
High-cholesterol diet increased TSLPR expression and atherosclerosis. High-dose ticagrelor moderated this trend. It modulated platelet activity and atherosclerosis mediated by TSLPR, potentially through the PI3K/Akt signal pathway. PMID:26517374
Activating thymic stromal lymphopoietin promotes atherosclerosis by inducing Th17/Treg imbalance through TSLPR signaling in a mouse model. PMID:25117469
TSLPR helps to create a permissive microenvironment for the development and pulmonary metastasis of mammary carcinoma in a mouse model using implanted 4T1 tumour cells. PMID:24033709
mice deficient in TSLP receptors on LCs abrogated the induction of OVA-specific IgE levels upon epicutaneous OVA sensitization. PMID:22385635
Increased susceptibility to autoimmune gastritis in thymic stromal lymphopoietin receptor-deficient mice. PMID:22124119
Presence of functional TSLP-specific receptor chain is required for the development of T helper cell type (Th)2 contact hypersensitivity to the hapten fluorescein isothiocyanate (FITC). PMID:20173025
Induced homodimerization of receptor chimeras containing the transmembrane and cytoplasmic domains of both human and mouse TSLP receptors is not sufficient for driving cell proliferation. PMID:20096461
expression pattern in antigen presenting cells PMID:11841846
B-cell development, including the IgM+ compartment, was unaffected by loss of the TSLPR pathway. PMID:14993294
molecular cloning of Tslpr in insect cells or COS cells resulted in expression of mTSLPR with an extracellular C-terminal end, a surprising result since the N-terminal region contains a signal sequence and two potential glycosylation sites PMID:15488943
local application of anti-TSLPR prevented Th2-mediated airway inflammation, at least partly, by regulating DCs function, which might be exploited to develop novel treatments for asthma. PMID:18757241

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Subcellular Location

[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

Protein Families

Type I cytokine receptor family, Type 5 subfamily

Tissue Specificity

High level of expression in liver, lung and testis. Also expressed in heart, brain, spleen, thymus and bone marrow. Highly expressed in progenitors and myeloid cells. Isoform 2 is expressed in primary hemotopoietic cells.

Database Links

UNIGENE: Mm.35771

KEGG: mmu:57914

STRING: 10090.ENSMUSP00000036326

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