Recombinant Mouse Cystatin-C (Cst3)

1. CysC plays an important regulatory role in combating cell death via the autophagic pathway in atherosclerosis. PMID:27079462
2. Data (including data from studies in mutant mice) suggest that up-regulation of Cst3, as observed in plasma of mice with type 2 diabetes, down-regulates insulin signaling and promotes endoplasmic reticulum stress in hepatocytes but not in myotubes. PMID:26592151
3. Cystatin C is a potential pathogenic signal triggering neurodegeneration in multiple system atrophy. PMID:24405769
4. The neuroprotective activity of CysC against Amyotrophic lateral sclerosis-linked mutant Cu/Zn-superoxide dismutase (SOD1)-mediated toxicity. PMID:25356866
5. an important role for macrophages, DC, and ROS in diseases associated with the protease inhibitory activity or amyloidogenic properties of cystatin C. PMID:24570004
6. APP expression stimulates NSPC proliferation; this effect is mediated via an increase in cystatin C secretion PMID:23671283
7. Cystatin C, a protein targeted to the classical secretory pathway by its signal peptide sequence, is secreted by primary neurons in at least 9 different cystatin C glycoforms associated with exosomes. PMID:19773092
8. The lack of cystatin C enhances Collagen-induced arthritis and primarily affects in vivo priming of the immune system PMID:21443774
9. Inflammation causes downregulation of cystatin C expression in dendritic cells and reduces serum CstC levels. PMID:21300820
10. Data show that the absence of cystatin C reduced epithelial cell apoptosis but increased proliferation in skin. PMID:21085595
11. Data show that cystatin C effectively rescues cystatin B loss-of-function mutation, facilitating the reversal of pathophysiological changes and suggesting a novel therapeutic intervention for patients with neurodegenerative disorders. PMID:20889561
12. CysC plays a protective role under conditions of neuronal challenge by inducing autophagy via mTOR inhibition PMID:20352108
13. Oxidants induce elevated cystatin C production from cardiac myocytes. Cystatin C plays a role in cardiac extracellular matrix remodelling. PMID:20489058
14. Data show that cystatin c (CystC) contributes to experimental abdominal aortic aneurysms (AAA) pathogenesis and that lack of CystC favors inflammation in AAA lesions induced in atherosclerotic mice. PMID:20472891
15. The embryo's cystatin C and F expression functions as a protective mechanism against the maternal proteinase cathepsin S. PMID:20093401
16. Cystatin C through this effect can act as an immunomodulatory molecule. PMID:19446036
17. expressed in decidual cultures and the expression is controlled in part by TGF-beta(1) and EGF signaling PMID:11803549
18. spatiotemporal up-regulation of cystatin C in the hippocampus is induced by entorhinal deafferentation (perforant path transections) PMID:12044447
19. Cystatin C is neither necessary nor sufficient to control expression of major histocompatibility type II complexes and antigen presentation in dendritic cells. PMID:14607896
20. In vivo overexpression of human cystatin C does not affect amyloid-beta levels in mice that do not deposit amyloid-beta. PMID:14742906
21. Data indicate that cystatin C is involved in astrocyte differentiation during mouse brain development. PMID:15509901
22. leukocyte-specific expression of cystatin C is actively involved in matrix remodelling associated with atherosclerosis plaque regression. PMID:15823274
23. the protective role of cystatin C in atherosclerosis is dependent primarily on its expression in nonhematopoietic cell types PMID:16051881
24. PKB activity is a critical downstream component of PDK-1 in mediating translation of cystatin C, RANKL, and Rab11a PMID:16166629
25. These data demonstrate that cystatin C has a role in neuronal death and neurogenesis during SE-induced network reorganization. PMID:16242633
26. Validity of cystatin C for generating neural stem cells from embryo stem cells in vitro. PMID:16595632
27. We propose that in MS, remyelination may be impaired by increasing activity of cathepsins inadequately controlled by cystatin C. PMID:17086443
28. Finally, in vivo studies using kidney-specific megalin knockout mice provide evidence that megalin mediates proximal tubular uptake of cystatin C. We conclude that megalin is an endocytic receptor of cystatin C in PTC. PMID:17462596
29. These results suggest that CysC affects the BMP signaling cascades in osteoblastic cells and then promotes osteoblast differentiation, mineralization, and bone formation. PMID:17592728
30. Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( PMID:18681831
31. CysC regulates soluble Abeta and Abeta-associated neuronal deficits through inhibiting CatB-induced Abeta degradation. PMID:18957217

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UNIGENE: Mm.4263

KEGG: mmu:13010

STRING: 10090.ENSMUSP00000028938