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Recombinant Mouse Cyclin-dependent kinase 4 inhibitor D (Cdkn2d)

Recombinant Mouse Cyclin-dependent kinase 4 inhibitor D (Cdkn2d)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Cdkn2d

Purity

>85% (SDS-PAGE)

Target Names

Cdkn2d

Uniprot NO.

Q60773

Alternative Names

Cdkn2d; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

1-166

Target Protein Sequence

MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG AQNLMDILQG HMMIPM
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Interacts strongly with CDK4 and CDK6 and inhibits them.

Gene References into Functions

Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d. PMID:26962681
p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging PMID:25458892
Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase CDK inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues. PMID:24687853
We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction PMID:24667034
an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos. PMID:22071115
Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner. PMID:22285491
A significant proportion of immortalised cell cultures apparently had neither a p53 mutation nor loss of p19/ARF. PMID:20378935
Deletion of Ink4d alone is sufficient to disrupt the maintenance of the post-mitotic state of sensory hair cells in post-natal mice. In Ink4d-/- animals, hair cells re-enter the cell cycle and undergo apoptosis, resulting in progressive hearing loss. PMID:12717441
Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. PMID:12941628
These studies indicate that a reduction in Ink4 family function by the loss of p19(Ink4d) is sufficient to induce mild reproductive defects in male mice with a mixed genetic background, but not in the C57BL/6 genetic background. PMID:17393423
p19(INK4D) knockdown led to a moderate increase (31.7% +/- 5%) in the mean ploidy of megakaryocytes suggesting a role of p19(INK4D) in the endomitotic arrest. PMID:18276842