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Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3 (Creb3l3), partial

Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3 (Creb3l3), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Creb3l3

Purity

>85% (SDS-PAGE)

Target Names

Creb3l3

Uniprot NO.

Q91XE9

Alternative Names

Creb3l3; CrebhCyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]

Species

Mus musculus (Mouse)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that may act during endoplasmic reticulum (ER) stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.

Gene References into Functions

CREB3L3 plays a crucial role in hepatic adaptation to energy starvation via two pathways: direct related gene regulation and an auto-loop activation of PPAR alpha. PMID:27982131
These results uncover a negative feedback loop in which CREBH regulates nonesterified fatty acid flux from adipose tissue to the liver via FGF21. PMID:27301791
CREBH mediates inflammatory signaling to VLDL overproduction in metabolic stress. Activation of CREBH in inflammation enhances mRNA and protein expression of apoB. CREBH presents a potential novel therapeutic target for hyperlipoproteinemia. PMID:28455595
key positive regulator of TGF-beta2 transcription in hepatitis C virus-infected cells PMID:28621467
TLR-4 interacts with CREBH to modulate high-density lipoprotein in response to bacterial endotoxin. PMID:27637329
CREBH functions as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under metabolic stress PMID:28461393
Ldlr(-/-) Creb3l3(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr(-/-) mice. PMID:27417587
studies reveal that CREBH functions as a circadian-regulated liver transcriptional regulator that integrates energy metabolism with circadian rhythm. PMID:27507854
Very Low Density Lipoprotein (VLDL) assembly and CREBH activation play key roles in the response to hepatic steatosis by up-regulating apoA-IV and promoting assembly and secretion of larger, more triglyceride - enriched VLDL particles. PMID:27655915
fasting or glucagon stimulation modulates lipid homeostasis through acetylation of CREBH. PMID:26438600
Overexpression of nuclear CREB3L3 induced systemic lipolysis, hepatic ketogenesis, and insulin sensitivity with increased energy expenditure. PMID:25233440
CREBH-Fsp27beta axis is important for regulating lipid droplet dynamics and triglyceride storage in the liver PMID:25125366
CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID:25428452
Alpha lipoic acid (ALA) increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21 PMID:25449271
Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID:24466039
analysis of the transcriptional regulatory axis of CREBH-PPARalpha-FGF21 that has a role in maintaining lipid homeostasis under metabolic stress PMID:24424044
These data demonstrate that CREBH is a positive regulator of CYP2B in response to sulpyrine administration, which possibly results in fatal shock. PMID:23409047
Data indicate that knockdown of Crebh or Cb1r antagonism attenuated 2-arachidonoylglycerol mediated induction of Lipin1 gene expression and decreased diacylglycerol production in liver and subsequently restored insulin receptor signaling. PMID:22989885
Studies indicate that CREB-H-deficient mice showed hypertriglyceridemia. PMID:22262056
Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. PMID:22095841
a transcription factor that has a crucial role in triglyceride metabolism PMID:21666694
CREBH plays a crucial role in the regulation of hepatic glucose metabolism in mammals. PMID:20374965
N-linked glycosylation is required for full activation of CREB-H through intramembrane proteolysis. PMID:20356926
Activation of CREBH at fasting through fatty acids and PPARalpha suggest that CREBH is involved in nutritional regulation. PMID:20006574
CREB-H is a liver-enriched bZIP transcription factor that may be involved in hepatic physiology and hepatocarcinogenesis. PMID:15800215
molecular mechanism for activation of an ER-localized transcription factor, CREBH PMID:16469704
HNF4alpha has a role in controlling the acute phase response of the liver induced by ER stress by regulating expression of CrebH. PMID:18704925

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

Exclusively expressed in adult liver (at protein level).

Database Links

UNIGENE: Mm.294693

KEGG: mmu:208677

STRING: 10090.ENSMUSP00000112836

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