Recombinant Mouse Complement factor D (Cfd)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

Cfd

Uniprot NO.

P03953

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

26-259

Target Protein Sequence

ILGGQ EAAAHARPYM ASVQVNGTHV CGGTLLDEQW VLSAAHCMDG VTDDDSVQVL LGAHSLSAPE PYKRWYDVQS VVPHPGSRPD SLEDDLILFK LSQNASLGPH VRPLPLQYED KEVEPGTLCD VAGWGVVTHA GRRPDVLHQL RVSIMNRTTC NLRTYHDGVV TINMMCAESN RRDTCRGDSG SPLVCGDAVE GVVTWGSRVC GNGKKPGVYT RVSSYRMWIE NITNGNMTS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Gene References into Functions

An essential role for Factor D in the ability of the liver to recover from acute toxic injury, is reported. PMID:25467802
The present study identifies adipsin, one of the most abundant and specifically expressed adipose proteins, as a circulating factor linking fat cells and obesity to beta cell function. PMID:24995977
Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin. PMID:24036114
Factor D-deficient mice lacking the alternative complement pathway show significantly reduced survival and increased organ dysfunction, following cecal ligation and puncture when compared with control mice. PMID:21263075
local expression of adipsin has a reproductive effect at the feto-maternal interface and possibly plays a role in spontaneous abortion PMID:20581430
MASP-1 converted pro-Df to the active form in vitro, although the activation mechanism of pro-Df by MASP-1 is still unclear. Thus, it is clear that MASP-1 is an essential protease of both the lectin and alternative complement pathways. PMID:20038603
Adipsin expression was not detected in any transfected clones of 3T3L1 cells exhibiting a complete blockage to differentiation. PMID:12558660
Adipsin is a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor PMID:12949072
Mesangial immune complex glomerulonephritis is due to Cfd deficiency. PMID:17410102
In the process of spontaneous abortion, the innate immune system through adipsin and complement C3 appears to be influential. PMID:18068164